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Authors
Luque-Ramírez, Manuel https://orcid.org/0000-0002-6002-4237
Martínez-García, María Ángeles
Insenser, María
Quintero-Tobar, Alejandra
de Lope Quiñones, Sara
Nattero-Chávez, Lía
Quiñones-Silva, Jhonatan
Escobar-Morreale, Héctor Francisco
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Funding
Funding for this research was provided by:
Instituto de Salud Carlos III (PI18/01122)
Instituto de Salud Carlos III (PI18/01122 and PI21/00116)
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Article History
Received: 23 April 2025
Accepted: 6 April 2026
First Online: 13 April 2026
Declarations
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: Based on the results of this work, M.L.-R., H.F.E.-M., M.A.M.-G., and M.I. have requested for grant of an European patent as inventors (submission number: 300553124; application number: EP25382105.2) which is currently pending. S.L.Q., A.Q.T., L.N.-C., and J.Q.-S. have no conflicts of interest.
: All experiments were performed in accordance with relevant guidelines and regulations. All research involving human research participants was also performed in accordance with the Declaration of Helsinki, and accomplished the law 3/2.018, of December 5, 2008, on the Protection of Personal Data and was accordance with the Regulation (EU) 2016/679 of the European Parliament and of the Council of April 27, 2016 on Data Protection. All patients and controls provided informed consents allowing us to include their data in a database for research purposes including this study. That research database was approved by the local Ethics Committee from Hospital Universitario Ramón y Cajal (Date of approval: 7-March-2002; Reference number: 12/02). The informed consent was revised and again approved by the same local Institutional Review Board on 2022, March 10.
