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Article History

Received: 8 December 2025

Accepted: 16 April 2026

First Online: 27 April 2026

Declarations

:

: The authors declare no competing interests.

: For the experimental validation component involving clinical sample collection and qRT-PCR analysis, this study was conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of The First Affiliated Hospital of Guangxi Medical University (approval number: 2024-E724-05). Written informed consent was obtained from all participants prior to tissue sample collection. Clinical samples included both non-diabetic control foot skin tissues and diabetic foot ulcer tissues, which were collected during routine clinical procedures. All patient information was anonymized to protect privacy, and samples were processed according to established institutional protocols for human tissue research.

: All authors have reviewed and approved the final version of the manuscript and consent to its submission for publication.