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In Vitro antileishmanial evaluation, molecular docking, dynamics simulations, and DFT Studies of tetrahydropyridine derivatives as potential trypanothione reductase inhibitors

Crossref DOI link: https://doi.org/10.1038/s41598-026-50258-y

Published Online: 2026-05-04

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Ataollahi, Elaheh

Sabet, Razieh

Hatam, Gholamreza

poustforoosh, Alireza

Dastkhosh, Nazi

Omidi, Atefe

Solhjoo, Aida

Zamani, Leila

Emami, Leila

Khabnadideh, Soghra
Funding

Funding for this research was provided by:

Shiraz University of Medical Sciences
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Text and Data Mining valid from 2026-05-04

Version of Record valid from 2026-07-03
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Article History

Received: 15 December 2025

Accepted: 20 April 2026

First Online: 4 May 2026

Declarations

:

: The authors declare no competing interests.

: This study utilized commercially available cell lines (Leishmania major promastigotes (strain MRHO/IR/75/ER)) obtained from the National Cell Bank of Iran (NCBI), and no human or animal subjects were directly involved. All experimental protocols followed standard guidelines for in vitro research, and no additional consent procedures were necessary.

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