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Bio inspired assessment of titanium-organic framework and exosome-constructed p-Synephrine carriage: pursuing the PI3K/mTOR pathway in a simulated periodontitis

Crossref DOI link: https://doi.org/10.1038/s41598-026-54070-6

Published Online: 2026-05-25

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Kishta, Mohamed S.

Elshaar, Abdelrahman H.

Makled, Rawan N.

Abdel-Aleem, Ghada A.

Makled, Mirhan N.

Abdelhameed, Reda M.
Funding

Funding for this research was provided by:

National Research Centre Egypt
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Text and Data Mining valid from 2026-05-25

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Article History

Received: 28 January 2026

Accepted: 17 May 2026

First Online: 25 May 2026

Declarations

:

: The authors declare no competing interests.

: The study protocol was approved by the ethics committee Kafrelsheikh University in Egypt’s which gave its approval for the procedures used to collect the extracted teeth (Ethical approval from Kafrelsheikh University with approval no KFS-272/2025 date 27/5/2025). All methods were performed in accordance with the relevant guidelines and regulations, including the Declaration of Helsinki. Written informed consent for participation and publication of experimental results was obtained from all donors and/or their legal guardians. All procedures involving human tissue were conducted in compliance with institutional ethical standards and donor consent protocols.

: All authors consent for participation and publication of this study.

: The authors declare that they have not used AI-generated work in this manuscript.

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