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Optimized cloning and expression of recombinant human type I collagen in mammalian cells using Ubiquitous Chromatin Opening Elements for enhanced protein production

Crossref DOI link: https://doi.org/10.1038/s41598-026-66825-2

Published Online: 2026-09-08

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Zahid, Khadija

Ahmed, Sameen

Ali, Amjad

Tao, Yizhi Jane

Turkistani, Areej

Waqas, Muhammad

Hassan, Shaimaa M.

Hussein, Khulood S.

Aljarba, Nada H.

AbdElrahman, Mohamed

El-Ghaiesh, Sabah H.

Idrees, Habiba

Afzal, Samia

Idrees, Muhammad

Rafique, Shazia
Funding

Funding for this research was provided by:

Princess Nourah bint Abdulrahman University Researchers Supporting Project (PNURSP2025R62)
License Information

Text and Data Mining valid from 2026-09-08

Accepted Manuscript valid from 2026-09-08
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Article History

Received: 2 August 2025

Accepted: 10 August 2026

First Online: 8 September 2026

Declarations

Competing interests: The authors declare no competing interests.

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