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Early renal replacement therapy and short-term mortality in higher-risk KDIGO stage 2 sepsis-associated acute kidney injury with sustained oliguria: a target trial emulation

Crossref DOI link: https://doi.org/10.1038/s41598-026-72476-0

Published Online: 2026-09-21

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Hu, Ende

Chen, Qian

Lin, Xiao https://orcid.org/0009-0003-5241-9073
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Text and Data Mining valid from 2026-09-21

Accepted Manuscript valid from 2026-09-21
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Article History

Received: 18 July 2026

Accepted: 16 September 2026

First Online: 21 September 2026

Declarations

Competing interests: The authors declare no competing interests.

Ethics approval and consent to participate: This study used the Medical Information Mart for Intensive Care IV version 3.1 (MIMIC-IV v3.1), a publicly available, de-identified critical care database. The establishment and release of MIMIC-IV were approved by the relevant institutional review boards of Beth Israel Deaconess Medical Center and the Massachusetts Institute of Technology. All patient-identifying information had been removed before database release. The investigators completed the required PhysioNet credentialing process and data use agreement before obtaining access to the database. Because this study was a secondary analysis of anonymized retrospective data and involved no direct patient contact or intervention, additional institutional ethical approval was not required. The requirement for written informed consent was waived in accordance with applicable regulations and institutional policies.

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