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Transcriptome-wide Mendelian randomization and single-cell analysis during CD4+ T cell activation deciphers immunotherapeutic targets for colorectal cancer

Crossref DOI link: https://doi.org/10.1038/s41698-025-01236-6

Published Online: 2025-12-29

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Cui, Kai

Zou, Qiuming

Qu, Xinyi

Yan, Yu

Lu, Meishan

Zhou, Xiaofeng

Liu, Lili

Shen, Yitong

Wang, Shihan

Zhuang, Xiaosong

Su, Jinxuan

Qin, Baifu

Ye, Wencai

Qi, Qi
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (82293680)

Science and Technology Projects in Guangzhou (202102070001)

Fundamental Research Funds for the Central Universities (21623109)

Basic and Applied Basic Research Foundation of Guangdong Province (2024A1515013108)
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Text and Data Mining valid from 2025-12-29

Version of Record valid from 2026-01-19
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Article History

Received: 6 June 2025

Accepted: 29 November 2025

First Online: 29 December 2025

Competing interests

: The authors declare no competing interests.

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