Document is current

Article History

Received: 11 September 2025

Accepted: 8 January 2026

First Online: 19 January 2026

Competing interests

: Y.N. reports advisory role from Guardant Health Pte Ltd., Natera, Inc., Exact Sciences Corporation, Tempus AI, Inc., Pfizer Inc., and Shionogi & Co., Ltd. Inc.; speakers’ bureau from MSD K.K., Merck Biopharma Co., Ltd., Daiichi Sankyo Co., Ltd., Chugai Pharmaceutical Co., Ltd., and, Guardant Health Japan Corp. J.G.R., P.N., J.B., P.S., J.J., Y.L., T.C., N.L., S.M., E.H., G.K., B.G., I.T., W.C., A.T., S.L.B., M.M., S.S., S.A.S., A.J., M.C.L., T.K., and A.A. are employees of Natera, Inc., with stock or options to own stock. YH is an employee of Natera, Inc., with stock or options to own stock and owns stock in GRAIL, Inc. MR reports employment at Natera, Inc., MyOme, and Marble Therapeutics; leadership roles at Natera, Inc., MyOme, and Marble Therapeutics; stock and other ownership interests in Natera, Inc., MyOme, and Marble Therapeutics; consulting or advisory role to Natera, Inc., MyOme, and Marble Therapeutics; research funding from Natera, Inc. and MyOme; patents, royalties or other intellectual property from Natera, Inc. and MyOme; and travel, accommodation, expenses from Natera, Inc. and MyOme. D.K. reports honoraria from Takeda, Chugai, Eli Lilly, MSD, Ono, Taiho, Bristol Myers Squibb, Daiichi-Sankyo, Pfizer, Eisai, Merckbiopharma, and Sysmex, and research funding from Ono, MSD, Novartis, Servier, Janssen, IQVIA, Syneoshealth, Cimic, and Cimicshiftzero. E.O. reports research funding from Guardant Health and honoraria from Ono, Takeda, Bayer, Chugai, Taiho, Eli Lilly, and Bristol Myers Squibb. TY reports honoraria from Chugai Pharmaceutical, Takeda Pharmaceutical, Merck Biopharma, Ono Pharmaceutical, and MSK; consulting fees from Indivumed and Sumitomo Corp; and research funding from Amgen, Bristol-Myers Squibb, Caris MPI, Chugai Pharmaceutical, Daiichi Sankyo, Eisai, Exact Sciences, FALCO Biosystems, Medical & Biological Laboratories, Merus N.V., Miyarisan Pharmaceutical, Molecular Health GmbH, MSD, Natera Inc., Nippon Boehringer Ingelheim, Ono Pharmaceutical, Pfizer Japan, Roche Diagnostics, Sanofi, Sysmex, Taiho Pharmaceutical, and Takeda Pharmaceutical.