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Cuproptosis-associated PDHA1 promotes sarcoma progression and immunotherapy responsiveness via the E2F1–PD-L1 axis: a multi-omics and clinical validation study

Crossref DOI link: https://doi.org/10.1038/s41698-026-01298-0

Published Online: 2026-03-06

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Qin, Haotian

Qi, Tiantian

Yao, Nan

Sheng, Weibei

Deng, Jinhao

Qian, Junyu

Wang, Deli

Zeng, Hui

Weng, Jian

Yang, Jun

Yu, Fei
Funding

Funding for this research was provided by:

Shenzhen Science and Technology Innovation Program (JCYJ20240813180905008)

Shenzhen Science and Technology Innovation Program (JCYJ20240813180905008)

Sanming Project of Medicine in Shenzen Municipality (No. SZSM202211038)

Sanming Project of Medicine in Shenzen Municipality (No. SZSM202211038)

Sanming Project of Medicine in Shenzen Municipality (No. SZSM202211038)
License Information

Text and Data Mining valid from 2026-03-06

Accepted Manuscript valid from 2026-03-06
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Article History

Received: 30 April 2025

Accepted: 18 January 2026

First Online: 6 March 2026

Competing interests

: The authors declare no competing interests.

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