Thielen, Natalie
Wei, Ning
Nagai, Emiko
Houston, Michele
Augenlicht, Leonard H.
Shin, Alice E.
Gabre, Joel T.
Rustgi, Anil K.
Ha, Grace
LaFave, Lindsay M.
Chu, Edward
Kitamura, Seiya
Kuang, Chaoyuan
Funding for this research was provided by:
National Institutes of Health (P30CA013330)
National Institutes of Health (P30CA013696)
National Institutes of Health (P30CA013696)
National Institutes of Health (P30CA013696)
National Institutes of Health (5T32CA200561)
National Institutes of Health (P30CA013330)
National Institutes of Health (R00GM138758)
National Institutes of Health (P30CA013330)
American Cancer Society (PF-23-1149774-01-MM)
American Gastroenterological Association (Research Scholar Award)
V Foundation (V Foundation Scholar Award)
A Breath of Hope Lung Foundation (Peg's Fight for Life Early Career Award)
Price Family Foundation
Article History
Received: 1 September 2025
Accepted: 14 March 2026
First Online: 8 April 2026
Competing interests
: N.T., S.K., N.W., E.N., and C.K. hold a patent application for the compound combinations described in this paper (Provisional Application U.S. No. 63/746,435). C.K. has the following disclosures: Teiko (consultant), Seattle Genetics (advisory board), Loki (collaboration/funding), BMS (advisory board), Guardant Health (advisory board), Exelixis (advisory board), Nuvectis Pharma (consultant). The remaining authors have no additional disclosures. The authors declare no financial competing interests.