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Article History

Received: 4 October 2025

Accepted: 14 April 2026

First Online: 13 May 2026

Competing interests

: S.E.L., M.P., C.S., A.K., T.P.-S., O.B., L.T., V.L., and A.S. were employees of Click Therapeutics, Inc. at the time of the study or are current employees. M.D. and S.J.T. serve as advisors for Click Therapeutics Inc. C.S. is an inventor on a patent related to an aspect of the CT-132 treatment, platforms for dynamically selecting messages in real-time to users via decision support tools, which was filed by Click Therapeutics, Inc., and is currently pending (EP4607535A3). S.J.T. has served as a speaker for AbbVie, Dr. Reddy’s, Eli Lilly, Lundbeck, Pfizer, Scilex, Teva, and Tonix. He has received honoraria for CME content from the American Academy of Neurology, American Headache Society, Annenberg Center for Health Sciences, Catamount Medical Education, Consortium for Research Education Social Awareness and Training In Neurosciences, Diamond Education Foundation, Forefront Collaborative, Haymarket Medical Education, HMP Global, Medical Education Speakers Network, Medical Learning Institute Peerview, Migraine Association of Ireland, Miller Medical Education, National Association for Continuing Education, North American Center for CME, The Ohio State University, Physicians’ Education Resource, PlatformQ Education, Primed, Vindico Medical Education, and WebMD/Medscape. He has received research funding from AbbVie, Aeon, Amgen, Annovis, Axsome, Cassava, Cognition, Eli Lilly, Inhibikase, Ipsen, Lundbeck, Merz, Neurolief, Pfizer, PrecisionMed, Revance, Scilex, Suven, and UCB. He has served as consultant and/or on advisory boards for AbbVie, Aeon, Alphasights, Amgen, Aruene/eNeura, Atheneum, Axsome Therapeutics, Bausch Health, Becker Pharmaceutical Consulting, Catch Therapeutics, ClearView Healthcare Partners, Click Therapeutics, CoolTech, CRG, Decision Resources, Defined Health, DRG, DocDelta, Dr. Reddy’s, Eli Lilly, ExpertConnect, FCB Health, Fenix, Gilmartin Capital, GLG, Guidepoint Global, Health Advances, Health Science Communications, HMP Communications, Impel, Initiator Pharma, InteractiveForums, IQVIA, Keyquest, Ki Health Partners, Krog and Partners, Lundbeck, M3Global Research, Magellan Health, Magnolia Innovation, Miravo Healthcare, MJH Holdings, Neurofront Therapeutics, Neurolief, Nocira, Novartis, P Value Communications, Pain Insights, Inc, Palion Medical, Perfood, Pfizer, Pulmatrix, Putnam Associates, Rehaler, SAI MedPartners, Satsuma, Scilex, Slingshot Insights, Spherix Global Insights, Strategy Inc, Synapse Medical Communication, System Analytic, Taylor & Francis, Tegus, Teva, Theranica, Third Bridge, Tonix, Trinity Partners, Unity HA, Vial, and XOC. He has received salary from Dartmouth-Hitchcock Medical Center, Thomas Jefferson University, and Ki Health Partners.