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Directed evolution of a highly efficient TNA polymerase achieved by homologous recombination

Crossref DOI link: https://doi.org/10.1038/s41929-024-01233-1

Published Online: 2024-10-01

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Maola, Victoria A. https://orcid.org/0000-0003-4913-0853
Yik, Eric J.

Hajjar, Mohammad https://orcid.org/0000-0002-9478-7216
Lee, Joy J. https://orcid.org/0009-0005-4471-7649
Holguin, Manuel J. https://orcid.org/0000-0002-2830-5303
Quijano, Riley N. https://orcid.org/0000-0003-0644-2697
Nguyen, Kalvin K. https://orcid.org/0009-0005-0582-4679
Ho, Katherine L. https://orcid.org/0009-0008-6933-0178
Medina, Jenny V. https://orcid.org/0009-0002-0833-7903
Chim, Nicholas https://orcid.org/0000-0003-2274-5305
Chaput, John C. https://orcid.org/0000-0003-1393-135X
Funding

Funding for this research was provided by:

National Science Foundation (MCB 1946312)

National Science Foundation (MCB 1946312)

National Science Foundation (MCB 1946312)

National Science Foundation (MCB 1946312)

National Science Foundation (MCB 1946312)

National Science Foundation (MCB 1946312)

National Science Foundation (MCB 1946312)

National Science Foundation (MCB 1946312)

National Science Foundation (MCB 1946312)

National Science Foundation (MCB 1946312)

National Science Foundation (MCB 1946312)
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Text and Data Mining valid from 2024-10-01

Version of Record valid from 2024-10-01
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Article History

Received: 8 December 2023

Accepted: 11 September 2024

First Online: 1 October 2024

Competing interests

: J.C.C., V.A.M., E.J.Y. and the University of California, Irvine have filed a patent application (PCT/US24/11595) on the composition and activity of the 10–92 TNA polymerase. The other authors declare no competing interests.

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