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Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

Crossref DOI link: https://doi.org/10.1038/s42003-022-03448-z

Published Online: 2022-06-13

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Winkler, Thomas W. https://orcid.org/0000-0003-0292-5421
Rasheed, Humaira https://orcid.org/0000-0002-3331-5864
Teumer, Alexander https://orcid.org/0000-0002-8309-094X
Gorski, Mathias

Rowan, Bryce X.

Stanzick, Kira J.

Thomas, Laurent F.

Tin, Adrienne https://orcid.org/0000-0002-4207-5866
Hoppmann, Anselm

Chu, Audrey Y.

Tayo, Bamidele

Thio, Chris H. L.

Cusi, Daniele

Chai, Jin-Fang

Sieber, Karsten B.

Horn, Katrin

Li, Man

Scholz, Markus

Cocca, Massimiliano https://orcid.org/0000-0002-1127-7596
Wuttke, Matthias

van der Most, Peter J. https://orcid.org/0000-0001-8450-3518
Yang, Qiong https://orcid.org/0000-0002-3658-1375
Ghasemi, Sahar

Nutile, Teresa

Li, Yong https://orcid.org/0000-0003-2651-8791
Pontali, Giulia https://orcid.org/0000-0002-4521-8981
Günther, Felix

Dehghan, Abbas https://orcid.org/0000-0001-6403-016X
Correa, Adolfo

Parsa, Afshin

Feresin, Agnese

de Vries, Aiko P. J.

Zonderman, Alan B.

Smith, Albert V. https://orcid.org/0000-0003-1942-5845
Oldehinkel, Albertine J.

De Grandi, Alessandro

Rosenkranz, Alexander R.

Franke, Andre https://orcid.org/0000-0003-1530-5811
Teren, Andrej

Metspalu, Andres https://orcid.org/0000-0002-3718-796X
Hicks, Andrew A. https://orcid.org/0000-0001-6320-0411
Morris, Andrew P.

Tönjes, Anke

Morgan, Anna

Podgornaia, Anna I.

Peters, Annette

Körner, Antje

Mahajan, Anubha

Campbell, Archie

Freedman, Barry I. https://orcid.org/0000-0003-0275-5530
Spedicati, Beatrice https://orcid.org/0000-0002-7432-4708
Ponte, Belen

Schöttker, Ben

Brumpton, Ben https://orcid.org/0000-0002-3058-1059
Banas, Bernhard

Krämer, Bernhard K.

Jung, Bettina

Åsvold, Bjørn Olav https://orcid.org/0000-0003-3837-2101
Smith, Blair H. https://orcid.org/0000-0002-5362-9430
Ning, Boting

Penninx, Brenda W. J. H.

Vanderwerff, Brett R.

Psaty, Bruce M. https://orcid.org/0000-0002-7278-2190
Kammerer, Candace M.

Langefeld, Carl D. https://orcid.org/0000-0002-4266-6949
Hayward, Caroline https://orcid.org/0000-0002-9405-9550
Spracklen, Cassandra N. https://orcid.org/0000-0003-3590-7182
Robinson-Cohen, Cassianne

Hartman, Catharina A.

Lindgren, Cecilia M.

Wang, Chaolong https://orcid.org/0000-0003-3945-1012
Sabanayagam, Charumathi https://orcid.org/0000-0002-4042-4719
Heng, Chew-Kiat https://orcid.org/0000-0002-7309-9473
Lanzani, Chiara

Khor, Chiea-Chuen https://orcid.org/0000-0002-1128-4729
Cheng, Ching-Yu https://orcid.org/0000-0003-0655-885X
Fuchsberger, Christian

Gieger, Christian https://orcid.org/0000-0001-6986-9554
Shaffer, Christian M.

Schulz, Christina-Alexandra

Willer, Cristen J. https://orcid.org/0000-0001-5645-4966
Chasman, Daniel I.

Gudbjartsson, Daniel F.

Ruggiero, Daniela

Toniolo, Daniela

Czamara, Darina https://orcid.org/0000-0001-7381-904X
Porteous, David J. https://orcid.org/0000-0003-1249-6106
Waterworth, Dawn M.

Mascalzoni, Deborah https://orcid.org/0000-0003-4156-1464
Mook-Kanamori, Dennis O.

Reilly, Dermot F.

Daw, E. Warwick

Hofer, Edith

Boerwinkle, Eric

Salvi, Erika

Bottinger, Erwin P.

Tai, E-Shyong https://orcid.org/0000-0003-2929-8966
Catamo, Eulalia

Rizzi, Federica https://orcid.org/0000-0002-4606-6553
Guo, Feng

Rivadeneira, Fernando https://orcid.org/0000-0001-9435-9441
Guilianini, Franco

Sveinbjornsson, Gardar

Ehret, Georg

Waeber, Gerard

Biino, Ginevra

Girotto, Giorgia

Pistis, Giorgio

Nadkarni, Girish N.

Delgado, Graciela E.

Montgomery, Grant W. https://orcid.org/0000-0002-4140-8139
Snieder, Harold https://orcid.org/0000-0003-1949-2298
Campbell, Harry

White, Harvey D.

Gao, He

Stringham, Heather M. https://orcid.org/0000-0002-2991-6392
Schmidt, Helena https://orcid.org/0000-0001-9773-9992
Li, Hengtong

Brenner, Hermann

Holm, Hilma https://orcid.org/0000-0002-9517-6636
Kirsten, Holgen

Kramer, Holly

Rudan, Igor

Nolte, Ilja M.

Tzoulaki, Ioanna

Olafsson, Isleifur

Martins, Jade https://orcid.org/0000-0001-6528-8947
Cook, James P.

Wilson, James F. https://orcid.org/0000-0001-5751-9178
Halbritter, Jan

Felix, Janine F. https://orcid.org/0000-0002-9801-5774
Divers, Jasmin

Kooner, Jaspal S. https://orcid.org/0000-0003-2086-4837
Lee, Jeannette Jen-Mai

O’Connell, Jeffrey

Rotter, Jerome I.

Liu, Jianjun https://orcid.org/0000-0002-3255-3019
Xu, Jie

Thiery, Joachim

Ärnlöv, Johan

Kuusisto, Johanna

Jakobsdottir, Johanna

Tremblay, Johanne

Chambers, John C.

Whitfield, John B.

Gaziano, John M.

Marten, Jonathan

Coresh, Josef https://orcid.org/0000-0002-4598-0669
Jonas, Jost B. https://orcid.org/0000-0003-2972-5227
Mychaleckyj, Josyf C. https://orcid.org/0000-0003-2595-0005
Christensen, Kaare https://orcid.org/0000-0002-5429-5292
Eckardt, Kai-Uwe

Mohlke, Karen L. https://orcid.org/0000-0001-6721-153X
Endlich, Karlhans

Dittrich, Katalin

Ryan, Kathleen A. https://orcid.org/0000-0003-1158-8455
Rice, Kenneth M. https://orcid.org/0000-0002-3071-7278
Taylor, Kent D.

Ho, Kevin

Nikus, Kjell

Matsuda, Koichi

Strauch, Konstantin

Miliku, Kozeta

Hveem, Kristian

Lind, Lars

Wallentin, Lars

Yerges-Armstrong, Laura M. https://orcid.org/0000-0003-0006-5237
Raffield, Laura M. https://orcid.org/0000-0002-7892-193X
Phillips, Lawrence S.

Launer, Lenore J. https://orcid.org/0000-0002-3238-7612
Lyytikäinen, Leo-Pekka

Lange, Leslie A.

Citterio, Lorena

Klaric, Lucija

Ikram, M. Arfan https://orcid.org/0000-0003-0372-8585
Ising, Marcus

Kleber, Marcus E.

Francescatto, Margherita

Concas, Maria Pina

Ciullo, Marina

Piratsu, Mario

Orho-Melander, Marju

Laakso, Markku https://orcid.org/0000-0002-3394-7749
Loeffler, Markus

Perola, Markus

de Borst, Martin H. https://orcid.org/0000-0002-4127-8733
Gögele, Martin https://orcid.org/0000-0003-4785-4348
Bianca, Martina La

Lukas, Mary Ann

Feitosa, Mary F.

Biggs, Mary L.

Wojczynski, Mary K. https://orcid.org/0000-0002-2420-162X
Kavousi, Maryam

Kanai, Masahiro https://orcid.org/0000-0001-5165-4408
Akiyama, Masato

Yasuda, Masayuki

Nauck, Matthias

Waldenberger, Melanie https://orcid.org/0000-0003-0583-5093
Chee, Miao-Li

Chee, Miao-Ling

Boehnke, Michael https://orcid.org/0000-0002-6442-7754
Preuss, Michael H. https://orcid.org/0000-0001-5266-8465
Stumvoll, Michael https://orcid.org/0000-0001-6225-8240
Province, Michael A.

Evans, Michele K.

O’Donoghue, Michelle L.

Kubo, Michiaki https://orcid.org/0000-0002-0095-2322
Kähönen, Mika

Kastarinen, Mika

Nalls, Mike A.

Kuokkanen, Mikko

Ghanbari, Mohsen https://orcid.org/0000-0002-9476-7143
Bochud, Murielle

Josyula, Navya Shilpa https://orcid.org/0000-0003-2782-8812
Martin, Nicholas G. https://orcid.org/0000-0003-4069-8020
Tan, Nicholas Y. Q.

Palmer, Nicholette D.

Pirastu, Nicola https://orcid.org/0000-0002-5363-3886
Schupf, Nicole

Verweij, Niek

Hutri-Kähönen, Nina

Mononen, Nina

Bansal, Nisha

Devuyst, Olivier

Melander, Olle

Raitakari, Olli T.

Polasek, Ozren

Manunta, Paolo

Gasparini, Paolo

Mishra, Pashupati P.

Sulem, Patrick https://orcid.org/0000-0001-7123-6123
Magnusson, Patrik K. E.

Elliott, Paul

Ridker, Paul M.

Hamet, Pavel

Svensson, Per O.

Joshi, Peter K. https://orcid.org/0000-0002-6361-5059
Kovacs, Peter https://orcid.org/0000-0002-0290-5423
Pramstaller, Peter P.

Rossing, Peter https://orcid.org/0000-0002-1531-4294
Vollenweider, Peter

van der Harst, Pim

Dorajoo, Rajkumar https://orcid.org/0000-0001-6608-2051
Sim, Ralene Z. H.

Burkhardt, Ralph

Tao, Ran

Noordam, Raymond https://orcid.org/0000-0001-7801-809X
Mägi, Reedik

Schmidt, Reinhold

de Mutsert, Renée

Rueedi, Rico

van Dam, Rob M.

Carroll, Robert J.

Gansevoort, Ron T.

Loos, Ruth J. F. https://orcid.org/0000-0002-8532-5087
Felicita, Sala Cinzia

Sedaghat, Sanaz

Padmanabhan, Sandosh

Freitag-Wolf, Sandra

Pendergrass, Sarah A.

Graham, Sarah E. https://orcid.org/0000-0003-1271-2489
Gordon, Scott D. https://orcid.org/0000-0001-7623-328X
Hwang, Shih-Jen

Kerr, Shona M. https://orcid.org/0000-0002-4137-1495
Vaccargiu, Simona

Patil, Snehal B.

Hallan, Stein

Bakker, Stephan J. L.

Lim, Su-Chi

Lucae, Susanne

Vogelezang, Suzanne

Bergmann, Sven https://orcid.org/0000-0002-6785-9034
Corre, Tanguy

Ahluwalia, Tarunveer S. https://orcid.org/0000-0002-7464-3354
Lehtimäki, Terho https://orcid.org/0000-0002-2555-4427
Boutin, Thibaud S. https://orcid.org/0000-0003-4754-1675
Meitinger, Thomas

Wong, Tien-Yin

Bergler, Tobias

Rabelink, Ton J. https://orcid.org/0000-0001-6780-5186
Esko, Tõnu

Haller, Toomas

Thorsteinsdottir, Unnur

Völker, Uwe https://orcid.org/0000-0002-5689-3448
Foo, Valencia Hui Xian

Salomaa, Veikko https://orcid.org/0000-0001-7563-5324
Vitart, Veronique https://orcid.org/0000-0002-4991-3797
Giedraitis, Vilmantas

Gudnason, Vilmundur https://orcid.org/0000-0001-5696-0084
Jaddoe, Vincent W. V. https://orcid.org/0000-0003-2939-0041
Huang, Wei

Zhang, Weihua https://orcid.org/0000-0001-8279-3611
Wei, Wen Bin

Kiess, Wieland

März, Winfried

Koenig, Wolfgang https://orcid.org/0000-0002-2064-9603
Lieb, Wolfgang https://orcid.org/0000-0003-2544-4460
Gao, Xin

Sim, Xueling https://orcid.org/0000-0002-1233-7642
Wang, Ya Xing https://orcid.org/0000-0003-2749-7793
Friedlander, Yechiel

Tham, Yih-Chung https://orcid.org/0000-0002-6752-797X
Kamatani, Yoichiro https://orcid.org/0000-0001-8748-5597
Okada, Yukinori https://orcid.org/0000-0002-0311-8472
Milaneschi, Yuri

Yu, Zhi https://orcid.org/0000-0003-4810-3474
,

Thio, Chris H. L.

van der Most, Peter J.

de Borst, Martin H.

,

Ho, Kevin

Josyula, Navya Shilpa

Pendergrass, Sarah A.

,

Rowan, Bryce X.

Robinson-Cohen, Cassianne

Gaziano, John M.

Phillips, Lawrence S.

Tao, Ran

Hung, Adriana M.

Stark, Klaus J.

Stefansson, Kari https://orcid.org/0000-0003-1676-864X
Böger, Carsten A.

Hung, Adriana M.

Kronenberg, Florian https://orcid.org/0000-0003-2229-1120
Köttgen, Anna https://orcid.org/0000-0002-4671-3714
Pattaro, Cristian https://orcid.org/0000-0002-4119-0109
Heid, Iris M. https://orcid.org/0000-0002-4122-5308
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Text and Data Mining valid from 2022-06-13

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Article History

Received: 16 December 2021

Accepted: 4 May 2022

First Online: 13 June 2022

Competing interests

: GlaxoSmithKline and Merck & Co employed A.Y.C. Janssen Pharmaceuticals and GlaxoSmithKline employed D.M.W. K.B.S., L.M.Y.-A. and M.A.L. are full-time employees of GlaxoSmithKline. M.S. receives funding from Pfizer Inc. for a project not related to this research. J.Ä. reports personal fees from AstraZeneca, Boehringer Ingelheim and Novartis, outside of the submitted work. D.F.G., H.H., K.S., P.S., G.S. and U.T. are employees of deCODE/Amgen Inc. Kevin Ho received support by Fresenius Medical Care North America. M.K. is employed with Synlab Holding Deutschland GmbH. W.K. reports consulting fees from AstraZeneca, Novartis, Pfizer, The Medicines Company, DalCor, Kowa, Amgen, Corvidia, Daiichi-Sankyo, Genentech, Novo Nordisk, Esperion, OMEICOS, LIB Therapeutics, speaker honoraria from Amgen, AstraZeneca, Novartis, Berlin-Chemie, Sanofi, and Bristol-Myers Squibb, and grants and non-financial support from Abbott, Roche Diagnostics, Beckmann, and Singulex, outside the submitted work. C.L. received Grants/ Research Support from Bayer Ag/ Novo Nordisk, Husband works for Vertex. As of January 2020, A.M. is an employee of Genentech, and a holder of Roche stock. W.M. is employed with Synlab Holding Deutschland GmbH. D.O.M.-K. is a partime research physician at Metabolon, Inc. M.A.N. was supported by a consulting contract between Data Tecnica International LLC and the National Institute on Aging (NIA), National Institutes of Health (NIH), Bethesda, MD, USA and consults for a number of small biotech and pharma. M.L.O. received grant support from GlaxoSmithKline during conduct of the study and received support from Novartis, Merck, Amgen, and AstraZeneca. L.S.P. has served on Scientific Advisory Boards for Janssen, and has or had research support from Merck, Pfizer, Eli Lilly, Novo Nordisk, Sanofi, PhaseBio, Roche, Abbvie, Vascular Pharmaceuticals, Janssen, Glaxo SmithKline, and the Cystic Fibrosis Foundation. He is also a cofounder, Officer and Board member and stockholder for a company, Diasyst, Inc., which markets software aimed to help improve diabetes management. A.I.P. and D.F.R. are employees of Merck Sharp Dohme Corp. Bruce.M.P. serves on the steering committee of the Yale Open Data Access Project funded by Johnson & Johnson. P.R. received fees to his institution for research support from AstraZeneca and Novo Nordisk; for steering group participation from AstraZeneca, Gilead, Novo Nordisk, and Bayer; for lectures from Bayer, Eli Lilly and Novo Nordisk; and for advisory boards from Sanofi and Boehringer Ingelheim outside of this work. V.S. has received a modest honorarium from Sanofi for consulting. He also has ongoing research collaboration with Bayer Ltd. (all outside of the present study). L.W. received institutional grants from GlaxoSmithKline, AstraZeneca, BMS, Boehringer-Ingelheim, Pfizer, MSD and Roche Diagnostics. H.W. has received grant support paid to the institution and fees for serving on Steering Committees of the ODYSSEY trial from Sanofi and Regeneron Pharmaceuticals, the ISCHEMIA and the MINT studies from the National Institutes of Health, the STRENGTH trial from Omthera Pharmaceuticals, the HEART-FID study from American Regent, the DAL-GENE study from DalCor Pharma UK Inc., the AEGIS-II study from CSL Behring, the SCORED and SOLOIST-WHF from Sanofi Aventis Australia Pty. Ltd., and the CLEAR OUTCOMES study from Esperion Therapeutics. M.P. is partly funded by the study FinnGen (), which is jointly funded by a Finnish Governmental agency Business Finland and thirteen international pharmaceutical companies: Abbvie, AstraZeneca, Biogen, Boehringer Ingelheim, Bristol-Myers Squibb, Genentech, a member of the Roche Group, GlaxoSmithKline (GSK), Janssen, Maze Therapeutics, MSD (the tradename of Merck & Co., Inc, Kenilworth, NJ USA), Novartis, Pfizer and Sanofi. C.C.K. is an Editorial Board Member for <i>Communications Biology</i>, but was not involved in the editorial review of, nor the decision to publish this article. The remaining authors declare no competing interests.

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