Enomoto, Masahiro https://orcid.org/0000-0002-9411-2999
Martinez-Valbuena, Ivan https://orcid.org/0000-0001-6463-6321
Forrest, Shelley L.
Xu, Xiaoxiao
Munhoz, Renato P.
Li, Jun
Rogaeva, Ekaterina https://orcid.org/0000-0002-2852-0329
Lang, Anthony E.
Kovacs, Gabor G. https://orcid.org/0000-0003-3841-5511
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Institute on Aging (R01AG080001)
Edmond J. Safra Philanthropic Foundation (None)
Article History
Received: 1 January 2025
Accepted: 6 June 2025
First Online: 16 June 2025
Competing interests
: GGK holds a shared patent for the 5G4 antibody used in the study. Other authors declare no competing interests.
: The brain was obtained at autopsy through appropriate consenting procedures with Local Ethical Committee approval. This study was approved by the UHN Research Ethics Board (Nr. 20-5258) and was performed per the ethical standards established in the 1964 Declaration of Helsinki, updated in 2008.