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A multi-tissue human knee single-cell atlas identifies that osteoarthritis reduces regenerative tissue stem cells while increasing inflammatory pain macrophages

Crossref DOI link: https://doi.org/10.1038/s42003-025-08586-8

Published Online: 2025-08-02

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Raut, Rajnikant Dilip

Chakraborty, Amit Kumar https://orcid.org/0000-0001-7455-6579
Neogi, Tuhina

Albro, Michael

Snyder, Brian

Schaer, Thomas P. https://orcid.org/0000-0002-4340-8212
Zhang, Chao https://orcid.org/0000-0001-8019-7998
Grinstaff, Mark W. https://orcid.org/0000-0002-5453-3668
Bais, Manish V. https://orcid.org/0000-0003-4198-7377
Funding

Funding for this research was provided by:

U.S. Department of Health & Human Services | NIH | National Institute of Dental and Craniofacial Research (R01 DE031413)
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Text and Data Mining valid from 2025-08-02

Version of Record valid from 2025-08-02
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Article History

Received: 23 April 2025

Accepted: 24 July 2025

First Online: 2 August 2025

Competing interests

: The authors declare no competing interests.

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