Li, Yingzhong https://orcid.org/0000-0002-4213-2496
Wu, Jiayu
Li, Na
Wu, Maoqing
Wang, Zongqi
Li, Jiahe https://orcid.org/0000-0002-9889-8546
Zhang, Libin https://orcid.org/0000-0002-6766-5109
Article History
Received: 6 February 2025
Accepted: 18 August 2025
First Online: 25 August 2025
Competing interests
: Y.L. and L.Z. are inventors patent of WO2025010420A2 “Compositions and methods for delivering molecules”, which invented the mRNA delivery ionizable lipid P6 for this study; patent of WO2023220693A1 “Synthetic self-amplifying mRNA molecules with secretion antigen and immunomodulator”, which invented one of the self-amplifying mRNA for this study; patent of Methods for cascade amplifications of PCT/US2025/019051 “Therapeutic payloads (CATP) & compositions for cancer immunotherapies and gene therapy” for this study. The other authors declare no competing interests.