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A feedforward loop between STAT1 and YAP1 stimulates lipid biosynthesis, accelerates tumor growth, and promotes chemotherapy resistance in mutant KRAS colorectal cancer

Crossref DOI link: https://doi.org/10.1038/s42003-025-08740-2

Published Online: 2025-08-25

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Wang, Shuo https://orcid.org/0000-0002-4640-8015
Diao, Shiqi https://orcid.org/0009-0005-9759-4638
Kim, Hyungdong

Zou, Jia Yi

Li, Ke Ke

Koromilas, Antonis E. https://orcid.org/0000-0003-1972-0799
Funding

Funding for this research was provided by:

Gouvernement du Canada | Canadian Institutes of Health Research (PJT-178173)

Canadian Cancer Society Research Institute (CCSRI #701631)
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Text and Data Mining valid from 2025-08-25

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Article History

Received: 11 October 2024

Accepted: 19 August 2025

First Online: 25 August 2025

Competing interests

: The authors declare no competing interests.

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