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SIRT5-mediated desuccinylation of MTHFD2 enhances chemoresistance in breast cancer cells by reducing therapy-induced senescence

Published Online: 2025-10-20

Authors

Xianhong, Zhang

Yue, Gao

Yu, Zhang

Yichen, Zhang

Yufei, Chen

Xinke, Pei

Jinhui, Zhang

Yiqi, Wang

Yitian, Du https://orcid.org/0000-0003-1655-3622
Shuailin, Hao https://orcid.org/0009-0007-1307-1288
Ting, Ni https://orcid.org/0000-0001-7007-1072
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (32400618, 92249302, 32370592)
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Text and Data Mining valid from 2025-10-20

Version of Record valid from 2025-10-20
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Article History

Received: 18 February 2025

Accepted: 11 September 2025

First Online: 20 October 2025

Competing interests

: The authors declare no competing interests.

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