Crossmark

Unveiling and stratifying cell cycle-dependent drug efficacy using a single-cell PLOM-CON approach with correlation anomaly and presage protein signals

Crossref DOI link: https://doi.org/10.1038/s42003-025-08916-w

Published Online: 2025-10-30

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Noguchi, Yoshiyuki

Kunishige, Rina https://orcid.org/0000-0002-0343-9735
Shinozaki-Narikawa, Naeko

Yamashita, Hiroshi https://orcid.org/0000-0002-6731-7673
Aihara, Kazuyuki

Murata, Masayuki

Kano, Fumi https://orcid.org/0000-0002-1903-8733
Funding

Funding for this research was provided by:

MEXT | Japan Society for the Promotion of Science (JPMJMS2021)

Japan Agency for Medical Research and Development (JP19gm6210015, JP23gm6410025)
License Information

Text and Data Mining valid from 2025-10-30

Version of Record valid from 2025-10-30
More Information

Article History

Received: 30 August 2024

Accepted: 22 September 2025

First Online: 30 October 2025

Competing interests

: M.M. and F.K. hold shares of Cellshoot Therapeutics, Inc. R.K., M.M., and F.K. are technical advisors of Cellshoot Therapeutics, Inc. Y.N. has been commissioned for mathematical analysis by Cellshoot Therapeutics, Inc. Y.N., R.K., M.M., and F.K. are inventors on a provisional patent related to this work filed by Tokyo Institute of Technology and the University of Tokyo (application no. 2022-111995). All remaining authors declare no competing interests.

Document is current

Any future updates will be listed below