Fletcher, Catherine T.
Mornement, Abigail A. https://orcid.org/0009-0004-6616-8727
Barrett, Charlotte
Canning, Peter
Rucktooa, Prakash
Huber, Sophie
Cooper, Christopher D. O.
Scully, Conor C. G.
Doré, Andrew S.
Rohle, Daniel
Smith, Geoffrey M. T.
Skerratt, Sarah E.
Kennedy, Amanda J. https://orcid.org/0000-0001-7650-406X
Article History
Received: 9 August 2025
Accepted: 12 January 2026
First Online: 28 January 2026
Competing interests
: All authors were employees of CHARM Therapeutics at the time of this work. CHARM previously pursued WRN inhibitor development, the program is no longer active, and this work was written up after its termination. Some authors are minor shareholders of CHARM Therapeutics, all other authors declare no competing interests.