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Cardiac-derived extracellular vesicles carrying miR-4433b-3p accelerate cognitive decline and brain aging by suppressing TP53INP2-mediated neuronal autophagy in mice

Crossref DOI link: https://doi.org/10.1038/s42003-026-10332-7

Published Online: 2026-06-04

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Cheng, Qian

Cui, Zhikang

Yu, Shuyi

Li, Guixia

Chen, Hang

Yu, Qian

Han, Jialin

Wu, Shuang

Jin, Yan

Wang, Yunshan https://orcid.org/0000-0001-5234-8752
Li, Ming https://orcid.org/0009-0002-9307-7009
Lu, Zhiming https://orcid.org/0000-0003-1228-5739
Funding

Funding for this research was provided by:

National Natural Science Foundation of China (82272414, 82572653)
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Text and Data Mining valid from 2026-06-04

Accepted Manuscript valid from 2026-06-04
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Article History

Received: 16 November 2025

Accepted: 13 May 2026

First Online: 4 June 2026

Competing interests

: The authors declare no competing interests.

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