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Article History

Received: 8 August 2024

Accepted: 23 October 2024

First Online: 5 November 2024

Competing interests

: M.S., M.B., D.K., A.K., T.S., R.M., J.H., K.C., J.C., and K.R. are coinventors on patent applications on natural and synthetic cystobactamids. All other authors declare no competing interests.

: Use of research animals or human research participants: For plasma stability experiments, samples were procured from commercial sources. Human plasma was obtained from Antibodies-online (catalog no. ABIN5706569), and mouse plasma was obtained from Tebubio (catalog no. D408-04-0050). The methods were performed in accordance with relevant guidelines and regulations and approved by the Helmholtz Centre for Infection Research. The animal studies were conducted in accordance with the recommendations of the European Community (Directive 2010/63/EU, 1st January 2013). All animal procedures were performed in strict accordance with the German regulations of the Society for Laboratory Animal Science (GV-SOLAS) and the European Health Law of the Federation of Laboratory Animal Science Associations (FELASA). The PK study was approved by the ethical board of the Niedersächsisches Landesamt für Verbraucherschutz und Lebensmittelsicherheit, Oldenburg, Germany.