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Mitochondria transfer-based therapies reduce the morbidity and mortality of Leigh syndrome

Crossref DOI link: https://doi.org/10.1038/s42255-024-01125-5

Published Online: 2024-09-02

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Nakai, Ritsuko http://orcid.org/0000-0002-7891-4879
Varnum, Stella http://orcid.org/0000-0002-4671-7088
Field, Rachael L. http://orcid.org/0009-0003-1717-9756
Shi, Henyun

Giwa, Rocky

Jia, Wentong

Krysa, Samantha J.

Cohen, Eva F.

Borcherding, Nicholas

Saneto, Russell P. http://orcid.org/0000-0002-7250-2347
Tsai, Rick C. http://orcid.org/0009-0000-5816-7303
Suganuma, Masashi http://orcid.org/0009-0006-8639-1365
Ohta, Hisashi

Yokota, Takafumi http://orcid.org/0000-0001-9358-8947
Brestoff, Jonathan R. http://orcid.org/0000-0002-7018-7400
Funding

Funding for this research was provided by:

Burroughs Wellcome Fund (CAMS #1019648)

U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (1R01NS134932, 5U54-NS078059-12)

MEXT | Japan Science and Technology Agency (JPMJSP #2138)

MEXT | Japan Society for the Promotion of Science (20K17379, 22K16322, 21K08415)

American Heart Association (24PRE1189775, 24POST1244220)

Washington University BioSURF award

W. M. Keck Foundation
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Article History

Received: 21 August 2023

Accepted: 8 August 2024

First Online: 2 September 2024

Competing interests

: R.C.T., H.O. and M.S. are employees of LUCA Science and are inventors on patents and/or pending patents related to MRC-Q (WO2024010862, WO2024010866). J.R.B. has pending patent applications related to the treatment of obesity (63/625,555) and allergic diseases (US20210128689A1), is a consultant for Columbus Instruments, has been a consultant for DeciBio in the past 12 months, is a member of the Scientific Advisory Board for LUCA Science, receives research support from LUCA Science for a project unrelated to this paper and receives royalties from Springer Nature Group. J.R.B., N.B. and R.L.F. are inventors of technology (Clambake) licensed to Columbus Instruments, which is not used in this paper. N.B. was employed by Omniscope within the past 12 months and holds equity in this company. R.P.S. receives research funding from Astellas (0367-CL-1201) that is unrelated to this paper. R.N. and T.Y. receive research support from LUCA Science. All other authors declare no competing interests.

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