Andres-Hernando, Ana
Orlicky, David J.
Garcia, Gabriela E.
Loetz, Esteban C.
Montoya, Richard
Kumar, Vijay
Effinger, Devin P.
Kuwabara, Masanari https://orcid.org/0000-0002-6601-4347
Bae, So Young https://orcid.org/0000-0001-6862-7166
Lorenzo-Rebenaque, Laura
Fauste, Elena https://orcid.org/0000-0002-5783-3092
Bell, Richard L. https://orcid.org/0000-0002-0525-0485
Grahame, Nicholas
Liangpunsakul, Suthat https://orcid.org/0000-0002-6504-8123
Kim, Hahn
Dugar, Sundeep
Maffuid, Paul
Nakagawa, Takahiko https://orcid.org/0000-0002-0127-1529
Wempe, Michael F.
Petrash, J. Mark https://orcid.org/0000-0002-6900-4240
Tolan, Dean R.
Bland, Sondra T.
Johnson, Richard J. https://orcid.org/0000-0003-3312-8193
Lanaspa, Miguel A. https://orcid.org/0000-0002-1163-1831
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (DK108859)
U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (DK121496)
U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (DK108408)
U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD096228)
U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (U24AA015512)
U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (U24AA013522)
U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (1U01AA027997)
EC | Directorate-General for Employment, Social Affairs and Inclusion | European Social Fund (CIBEST/2023/237)
Article History
Received: 1 April 2024
Accepted: 30 September 2025
First Online: 10 November 2025
Competing interests
: R.J.J. and M.A.L. have several patents and patent applications related to blocking fructose metabolism in the treatment of metabolic diseases and alcohol use disorder. H.K., S.D., P.M., M.F.W., D.R.T., R.J.J. and M.A.L. are also members of Colorado Research Partners LLC, which is developing inhibitors of fructose metabolism. R.J.J. also has some shares with XORT Therapeutics, which is a start-up company developing novel xanthine oxidase inhibitors. The other authors declare no competing interests.