Rosenkranz, Sina C. https://orcid.org/0000-0002-5228-4266
da Rocha, Joana F. https://orcid.org/0000-0002-2496-4061
Moreira, Luis
Schlachter, Pius https://orcid.org/0009-0009-3686-3952
Bier, Jasmina https://orcid.org/0000-0003-2330-0797
Healy, Kaela
Silva, Daniela Neves
Iqbal, Mohamed Ariff https://orcid.org/0000-0002-5094-0717
Gharagozloo, Marjan https://orcid.org/0000-0002-2166-4012
Xiong, Yueyue
Murphy, Matthew A. https://orcid.org/0000-0002-0905-748X
Lichtenfeld, Helena C.
Raich, Lukas
Schweizer, Michaela
Ertaş, Asude
Woo, Marcel S. https://orcid.org/0000-0002-1306-2708
Vieira, Vanessa
Honeycutt, Samuel E.
White, James P. https://orcid.org/0000-0003-2667-0806
Wyant, Gregory A.
Friese, Manuel A. https://orcid.org/0000-0001-6380-2420
Calabresi, Peter A. https://orcid.org/0000-0002-7776-6472
Sîrbulescu, Ruxandra F.
Wrann, Christiane D. https://orcid.org/0000-0001-6066-8799
Article History
Received: 28 November 2024
Accepted: 30 March 2026
First Online: 21 May 2026
Competing interests
: C.D.W. holds a patent related to irisin (WO2015051007A1). C.D.W. is an academic cofounder and consultant for Aevum Therapeutics. C.D.W. has a financial interest in Aevum Therapeutics, a company developing drugs which harness the protective molecular mechanisms of exercise to treat neurodegenerative and neuromuscular disorders. C.D.W. received honoraria from Novartis outside the scope of this work. The interests of C.D.W. were reviewed and are managed by Massachusetts General Hospital and Mass General Brigham in accordance with their conflict of interest policies. S.C.R. has received speaker honoraria from Merck, Roche and Sanofi, all outside of this work. P.A.C. has received consulting fees from Lilly and Novartis and is principle investigator on a grant to JHU from Genentech. M.S.W. received honoraria from Lilly and Eisai outside the scope of this work. All other authors declare no competing interests. A provisional patent application has been submitted by The General Hospital Corporation, listing C.D.W., S.C.R. and R.F.S. as inventors, based on the information contained in in this manuscript.