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Network-based systems pharmacology reveals heterogeneity in LCK and BCL2 signaling and therapeutic sensitivity of T-cell acute lymphoblastic leukemia

Crossref DOI link: https://doi.org/10.1038/s43018-020-00167-4

Published Online: 2021-01-21

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Gocho, Yoshihiro

Liu, Jingjing https://orcid.org/0000-0002-8184-8382
Hu, Jianzhong

Yang, Wentao

Dharia, Neekesh V. https://orcid.org/0000-0001-5048-067X
Zhang, Jingliao

Shi, Hao

Du, Guoqing

John, August

Lin, Ting-Nien

Hunt, Jeremy

Huang, Xin

Ju, Bensheng

Rowland, Lauren

Shi, Lei

Maxwell, Dylan

Smart, Brandon

Crews, Kristine R. https://orcid.org/0000-0002-7558-558X
Yang, Wenjian

Hagiwara, Kohei

Zhang, Yingchi

Roberts, Kathryn https://orcid.org/0000-0001-7626-4043
Wang, Hong

Jabbour, Elias

Stock, Wendy

Eisfelder, Bartholomew

Paietta, Elisabeth

Newman, Scott

Roti, Giovanni

Litzow, Mark

Easton, John

Zhang, Jinghui https://orcid.org/0000-0003-3350-9682
Peng, Junmin https://orcid.org/0000-0003-0472-7648
Chi, Hongbo

Pounds, Stanley https://orcid.org/0000-0002-9167-2114
Relling, Mary V. https://orcid.org/0000-0002-3720-9591
Inaba, Hiroto https://orcid.org/0000-0003-0605-7342
Zhu, Xiaofan

Kornblau, Steven https://orcid.org/0000-0002-5990-9548
Pui, Ching-Hon https://orcid.org/0000-0003-0303-5658
Konopleva, Marina https://orcid.org/0000-0002-9347-2212
Teachey, David https://orcid.org/0000-0001-7373-8987
Mullighan, Charles G. https://orcid.org/0000-0002-1871-1850
Stegmaier, Kimberly https://orcid.org/0000-0003-0218-7895
Evans, William E. https://orcid.org/0000-0002-9333-5322
Yu, Jiyang https://orcid.org/0000-0003-3629-4330
Yang, Jun J. https://orcid.org/0000-0002-0770-9659
Funding

Funding for this research was provided by:

U.S. Department of Health & Human Services | National Institutes of Health
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Article History

Received: 17 July 2020

Accepted: 14 December 2020

First Online: 21 January 2021

Competing interests

: N.V.D. is a current employee of Genentech, Inc., a member of the Roche Group. S.N. is a current employee of Sema4 Inc. K.S. currently has funding from Novartis International AG and has previously consulted for Rigel Pharmaceuticals on topics unrelated to this manuscript. M.V.R. J.J.Y. and St. Jude receive investigator-initiated research funding from Servier for work unrelated to this manuscript. J.J.Y. and J.Y. are also named as co-inventors on a pending provisional US patent application filed by St. Jude based on this research.

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