Crossmark

Targeting TGFβ-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome

Crossref DOI link: https://doi.org/10.1038/s43018-024-00764-7

Published Online: 2024-05-13

Update policy: https://doi.org/10.1007/springer_crossmark_policy

Authors

Vinnakota, Janaki Manoja

Biavasco, Francesca

Schwabenland, Marius https://orcid.org/0000-0003-2205-5427
Chhatbar, Chintan

Adams, Rachael C.

Erny, Daniel https://orcid.org/0000-0001-6000-8838
Duquesne, Sandra

El Khawanky, Nadia

Schmidt, Dominik https://orcid.org/0000-0002-7744-1248
Fetsch, Viktor

Zähringer, Alexander

Salié, Henrike https://orcid.org/0000-0002-2993-3782
Athanassopoulos, Dimitrios

Braun, Lukas M. https://orcid.org/0000-0003-0770-4994
Javorniczky, Nora R.

Ho, Jenny N. H. G.

Kierdorf, Katrin https://orcid.org/0000-0002-9272-4780
Marks, Reinhard

Wäsch, Ralph https://orcid.org/0000-0002-0813-3444
Simonetta, Federico

Andrieux, Geoffroy https://orcid.org/0000-0002-5389-9481
Pfeifer, Dietmar

Monaco, Gianni

Capitini, Christian https://orcid.org/0000-0002-2276-6731
Fry, Terry J. https://orcid.org/0000-0001-8044-5226
Blank, Thomas https://orcid.org/0000-0002-3969-405X
Blazar, Bruce R. https://orcid.org/0000-0002-9608-9841
Wagner, Eva https://orcid.org/0000-0002-0728-2253
Theobald, Matthias

Sommer, Clemens

Stelljes, Matthias

Reicherts, Christian

Jeibmann, Astrid

Schittenhelm, Jens

Monoranu, Camelia-Maria

Rosenwald, Andreas

Kortüm, Martin https://orcid.org/0000-0002-7011-0286
Rasche, Leo https://orcid.org/0000-0002-9536-9649
Einsele, Hermann https://orcid.org/0000-0002-7680-0819
Meyer, Philipp T.

Brumberg, Joachim

Völkl, Simon

Mackensen, Andreas

Coras, Roland

von Bergwelt-Baildon, Michael

Albert, Nathalie L.

Bartos, Laura M.

Brendel, Matthias

Holzgreve, Adrien https://orcid.org/0000-0002-9566-8438
Mack, Matthias https://orcid.org/0000-0002-3157-7262
Boerries, Melanie https://orcid.org/0000-0002-3670-0602
Mackall, Crystal L. https://orcid.org/0000-0001-6323-4304
Duyster, Justus

Henneke, Philipp

Priller, Josef

Köhler, Natalie https://orcid.org/0000-0002-7502-0431
Strübing, Felix https://orcid.org/0000-0002-9436-6294
Bengsch, Bertram https://orcid.org/0000-0003-2552-740X
Ruella, Marco https://orcid.org/0000-0003-4301-5811
Subklewe, Marion https://orcid.org/0000-0001-9154-9469
von Baumgarten, Louisa https://orcid.org/0000-0002-6634-0927
Gill, Saar

Prinz, Marco https://orcid.org/0000-0002-0349-1955
Zeiser, Robert https://orcid.org/0000-0001-6565-3393
License Information

Text and Data Mining valid from 2024-05-13

Version of Record valid from 2024-05-13
More Information

Article History

Received: 18 April 2023

Accepted: 27 March 2024

First Online: 13 May 2024

Ethics and inclusion statement

: All authors that made significant contributions are listed according to the Nature Portfolio guidelines.

: M.R. holds multiple patents related to CAR T cell immunotherapy that are managed by the University of Pennsylvania. M.R. has served as a consultant for nanoString, BMS, GSK, GLG, Bayer and AbClon. M.R. receives research funding from AbClon, Beckman Coulter and Oxoford Nano Imaging. M.R. is the scientific founder of viTToria biotherapeutics. R.Z. has served as a consultant for Novartis, Incyte, MNK and Sanofi. S.G. has patents related to CAR therapy with royalties paid from Novartis to the University of Pennsylvania. S.G. is a scientific cofounder and holds equity in Interius Biotherapeutics and Carisma Therapeutics. S.G. is a scientific advisor to Carisma, Cartography, Currus, Interius, Kite, NKILT, Mission Bio and Vor Bio. All other authors declare no conflicts of interest.

Document is current

Any future updates will be listed below