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Article History
Received: 4 December 2024
Accepted: 24 November 2025
First Online: 26 January 2026
Competing interests
: N.L. has received speaking honoraria from Illumina and is an advisory board member for FYR Diagnostics and Everygene; N.L. has also received research collaborative funding (for work unrelated to this publication) from Illumina and PacBio. J.A.L., K.M.L. and C.T.C. report grants from Alnylam Pharmaceuticals, Astellas Pharma, AstraZeneca Pharmaceuticals, Biodesix, Celgene Corporation, Cerner Enviza, GSK, IQVIA, Janssen Pharmaceuticals, Novartis International and the Parexel International Corporation through the University of Utah or Western Institute for Veteran Research outside the submitted work. A.S.K. reports funding (for work unrelated to this publication) from Janssen, Pfizer, Profound, Bristol Myers Squibb and Merck. S.L.D. reports grants from AstraZeneca Pharmaceuticals, Biodesix, Myriad Genetic Laboratories, Parexel, Moderna, GlaxoSmithKline, Cerner Enviza, Janssen Research & Development, Celgene, Novartis Pharmaceuticals, IQVIA, Astellas Pharma and Alnylam Pharmaceuticals. R.A.E. reports speaking honoraria from GU-ASCO, Janssen, University of Chicago and the Dana Farber Cancer Institute, educational honorarium from Bayer and Ipsen, being a member of external expert committee to AstraZeneca UK and Member of Active Surveillance Movember Committee and is a member of the Scientific Advisory Board of Our Future Health; she additionally undertakes private practice as a sole trader at The Royal Marsden NHS Foundation Trust and 90 Sloane Street SW1X 9PQ and 280 Kings Road SW3 4NX, London, UK. L.A.M. reports research funding from AstraZeneca to Harvard University; she holds equity in Convergent Therapeutics. T.M.S. reports honoraria from Varian Medical Systems, WebMD, GE Healthcare and Janssen; he has an equity interest in CorTechs Labs and serves on its Scientific Advisory Board; he receives research funding from GE Healthcare through the University of California, San Diego. These companies might potentially benefit from the research results. The terms of this arrangement have been reviewed and approved by the University of California, San Diego in accordance with its conflict-of-interest policies. All other authors declare no competing interests.