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Authors
Wong, Alan Y. L. https://orcid.org/0000-0001-5908-6820
Myers, Jacob W.
Prakash, Gyan
Ma, Alice
Brook, Jeannette R.
Petrova, Boryana https://orcid.org/0000-0001-9996-9353
Bulut, Baran https://orcid.org/0009-0006-2186-3245
White, Ralph III
Merz, Catherine https://orcid.org/0009-0001-5319-1790
de Souza, Maeve
Maynard, Adam G.
Wang, Peng
Yu, Amy https://orcid.org/0000-0003-2936-5225
Pohl, Nancy K. https://orcid.org/0000-0002-9173-3247
Weitman, Michal
Silverman, Lewis B.
Stegmaier, Kimberly https://orcid.org/0000-0003-0218-7895
Churchman, L. Stirling
Cole, Peter D. https://orcid.org/0000-0002-3525-8015
Brady, Donita C. https://orcid.org/0000-0002-2786-2802
Kanarek, Naama https://orcid.org/0000-0002-2068-3908
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Funding
Funding for this research was provided by:
Pew Charitable Trusts
Gabrielle's Angel Foundation for Cancer Research
U.S. Department of Health & Human Services | NIH | National Cancer Institute (1 RO1 CA279550-01)
Richard and Susan Smith Family Foundation (Excellence in Biomedical research)
Pharmaceutical Research and Manufacturers of America Foundation (Predoctoral Fellowship in Drug Discovery 2025)
Gouvernement du Canada | Canadian Institutes of Health Research (DFD-181606)
Croucher Foundation
NSF | BIO | Division of Molecular and Cellular Biosciences (GFRP)
U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (1 F31 HL178310-01)
Ludwig Institute for Cancer Research (Ludwig Princeton Branch)
U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (5R35GM124749)
U.S. Department of Health & Human Services | NIH | National Institute on Aging (R21AG091645)
U.S. Department of Health & Human Services | NIH | National Institute on Aging (R21AG091645)
K.S. receives support from Team Crank and the Children's Leukemia Research
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Article History
Received: 18 June 2025
Accepted: 23 April 2026
First Online: 25 May 2026
Competing interests
: A.Y.W. and N.K. hold a provisional patent application (37314-0156P01) for the use of copper-depleting therapies to boost the effect of chemotherapy. D.C.B. holds ownership in Merlon and Elaeis Therapeutics. L.B.S. served on an advisory board for Servier Pharmaceuticals and serves as a consultant and on an advisory board and speaker’s bureau for Jazz Pharmaceuticals. D.C.B. is an inventor on patent application 20150017261 entitled ‘Methods of treating and preventing cancer by disrupting the binding of copper in the MAP kinase pathway’. K.S. is a member of the scientific advisory board and has stock options with Auron Therapeutics on topics unrelated to the work. The other authors declare no competing interests.
