Pathak, Asmita
Sravya, Palavalasa
Colon, Bruno
Ciervo, Erika https://orcid.org/0009-0007-9351-368X
Zhou, Yadi
Teran Pumar, Oriana Y.
León, Brandon Emanuel
Mitchell, Jonathan
Assenza Tavares Coroa, Pedro Henrique
Mateo-Victoriano, Beatriz
Scott, Andrew J.
Gannamedi, Durga Prasad
Wong, Harrison K. A.
Zhang, Li
Lee, Juyeun
Kay, Kristen
Karaca, Efe
Chin, Diana H. https://orcid.org/0000-0002-1645-3552
Amirian, Haleh
Karaman, Irem https://orcid.org/0000-0001-7559-9095
Shrestha, Preyasha https://orcid.org/0009-0001-5120-5925
Sellick, Katelyn
Dean, Danielle
Bilbao Cortes, Daniel https://orcid.org/0000-0003-1630-8811
Datta, Jashodeep https://orcid.org/0000-0003-2869-1571
Welford, Scott M.
Franco, Maria Clara
Kurmi, Kiran
Shah, Ashish H. https://orcid.org/0000-0002-0183-1274
Cheng, Feixiong https://orcid.org/0000-0002-1736-2847
Lathia, Justin D. https://orcid.org/0000-0003-3168-7290
Rai, Priyamvada https://orcid.org/0000-0001-7822-7553
Lombard, David B. https://orcid.org/0000-0002-4292-0185
Lyssiotis, Costas A. https://orcid.org/0000-0001-9309-6141
Watson, Dionysios C.
Ceccarelli, Michele https://orcid.org/0000-0002-4702-6617
Wahl, Daniel R. https://orcid.org/0000-0001-9894-5085
Bayik, Defne https://orcid.org/0000-0002-4740-8869
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Cancer Institute (R00 CA248611)
U.S. Department of Health & Human Services | NIH | National Cancer Institute (F31 CA264849)
U.S. Department of Health & Human Services | NIH | National Cancer Institute (R01CA187053)
U.S. Department of Health & Human Services | NIH | National Cancer Institute (P01 CA245705)
U.S. Department of Health & Human Services | NIH | National Cancer Institute (R01CA254100)
U.S. Department of Health & Human Services | NIH | National Cancer Institute (R01CA253986)
U.S. Department of Health & Human Services | NIH | National Cancer Institute (R00CA277242)
U.S. Department of Health & Human Services | NIH | National Cancer Institute (K08CA234416)
U.S. Department of Health & Human Services | NIH | National Cancer Institute (P50CA269022)
U.S. Department of Health & Human Services | NIH | National Cancer Institute (R37CA258346)
U.S. Department of Health & Human Services | NIH | National Cancer Institute (K99CA300923)
U.S. Department of Health & Human Services | NIH | National Cancer Institute (F32CA260735)
American Brain Tumor Association (DG 2300253)
Velosano, Sylvester Comprehensive Cancer Center
American Cancer Society (PF-23-1077428-01-MM)
Cleveland Clinic Global Center
U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (R01DK132669)
U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK020593)
U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK058404)
U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (R35 NS127083)
Cleveland Clinic, Case Comprehensive Cancer Center
Sontag Foundation
Sylvester Comprehensive Cancer Center
Ben and Catherine Ivy Foundation
Alex's Lemonade Stand Foundation for Childhood Cancer
ChadTough Foundation
Forbes Institute for Cancer Discovery, Rogel Cancer Center
Article History
Received: 23 July 2024
Accepted: 22 May 2026
First Online: 23 June 2026
Ethics
Competing interests: In the past 3 years, C.A.L. has consulted for Astellas Pharmaceuticals, Odyssey Therapeutics, Third Rock Ventures and T-Knife Therapeutics; he is also listed as an inventor on patents pertaining to KRAS-regulated metabolic pathways, redox control pathways in pancreatic cancer and targeting the GOT1–ME1 pathway as a therapeutic approach (US patent nos. 2015126580-A1 and 20190136238; international patent no. WO2013177426-A2). A.J.S. reports being named as an inventor on a patent application not relevant to this work. J.D.L reports being named as a coinventor on pending and issued patents held by the Cleveland Clinic relating to cancer therapies, which are not directly relevant to this work. D.R.W. has consulted for Agios Pharmaceuticals, Admare Pharmaceuticals, Bruker and Innocrin Pharmaceuticals. D.R.W. is listed as an inventor on patents pertaining to the treatment of brain tumors (US provisional patent applications 63/416,146, 62/744,342 and 62/724,337). The other authors declare no competing interests.