Heo, Gyujin https://orcid.org/0000-0003-3499-2848
Xu, Ying
Wang, Erming
Ali, Muhammad https://orcid.org/0000-0002-1399-6631
Oh, Hamilton Se-Hwee https://orcid.org/0000-0001-8192-7593
Moran-Losada, Patricia
Anastasi, Federica https://orcid.org/0000-0002-9304-5421
González Escalante, Armand
Puerta, Raquel https://orcid.org/0000-0002-1191-5893
Song, Soomin https://orcid.org/0009-0003-3201-6031
Timsina, Jigyasha
Liu, Menghan
Western, Daniel https://orcid.org/0000-0003-3725-9553
Gong, Katherine https://orcid.org/0009-0008-7614-9545
Chen, Yike
Kohlfeld, Pat https://orcid.org/0009-0004-9206-8244
Flynn, Allison
Thomas, Alvin G. https://orcid.org/0000-0003-4911-8192
Lowery, Joseph
Morris, John C.
Holtzman, David M. https://orcid.org/0000-0002-3400-0856
Perlmutter, Joel S. https://orcid.org/0000-0003-3263-8917
Schindler, Suzanne E. https://orcid.org/0000-0002-1680-1465
Vilor-Tejedor, Natalia https://orcid.org/0000-0003-4935-6721
Suárez-Calvet, Marc https://orcid.org/0000-0002-2993-569X
García-González, Pablo https://orcid.org/0000-0003-0125-5403
Marquié, Marta
Fernández, Maria Victoria
Boada, Mercè https://orcid.org/0000-0003-2617-3009
Cano, Amanda
Ruiz, Agustín
Zhang, Bin
Bennett, David A.
Benzinger, Tammie https://orcid.org/0000-0002-8114-0552
Wyss-Coray, Tony https://orcid.org/0000-0001-5893-0831
Ibanez, Laura
Sung, Yun Ju https://orcid.org/0000-0002-8021-4070
Cruchaga, Carlos https://orcid.org/0000-0002-0276-2899
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Institute on Aging (R01AG044546)
Article History
Received: 27 September 2024
Accepted: 9 April 2025
First Online: 20 May 2025
Competing interests
: C.C. has received research support from GSK and Eisai. C.C. is a member of the scientific advisory board of Circular Genomics and owns stocks. C.C. is a member of the scientific advisory board of ADmit. There is an invention disclosure for the prediction models, including protein IDs, alternative proteins and weights, cutoff and algorithms. C.C. has served on the scientific advisory boards of GSK and Novo Nordisk. D.M.H. is a cofounder with equity in C2N Diagnostics. D.M.H. is on the scientific advisory boards of Genentech, Denali, C2N Diagnostics and Cajal Neurosciences. D.M.H. consults for Asteroid, Acta Pharmaceuticals, Alnylam, Pfizer and Switch. T.W.-C. and H.S.-H.O. are cofounders and scientific advisors of Teal Omics and have received equity stakes. T.W.-C. is a cofounder and scientific advisor of Alkahest and Qinotto and has received equity stakes in these companies. S.E.S. has served on scientific advisory boards on biomarker testing and clinical care pathways for Eisai and Novo Nordisk and has received speaking fees for presentations on biomarker testing from Eisai, Eli Lilly and Novo Nordisk. M.S.-C. has received consultancy/speaker fees (paid to the institution) from Almirall, Eli Lilly, Novo Nordisk and Roche Diagnostics in the past 36 months. M.S.-C. has received consultancy fees or served on the advisory boards (paid to the institution) of Eli Lilly, Grifols, Novo Nordisk and Roche Diagnostics. M.S.-C. was granted a project and is a site investigator of a clinical trial (funding granted to the institution) by Roche Diagnostics. M.S.-C. did not receive any personal compensation from these organizations or any other for-profit organization. The other authors declare no competing interests.