Elyahu, Yehezqel
Feygin, Ilana
Eremenko, Ekaterina
Pinkas, Noa
Zemer, Alon
Shicht, Amit
Berner, Omer
Avigdory-Meiri, Roni
Nemirovsky, Anna
Reshef, Keren https://orcid.org/0009-0004-1709-5031
Roitman, Lior
Krizhanovsky, Valery https://orcid.org/0000-0002-3977-5482
Monsonego, Alon https://orcid.org/0000-0002-4888-7865
Funding for this research was provided by:
Israel Science Foundation (3-16148)
Litwin and Gural Foundations
Article History
Received: 12 January 2024
Accepted: 30 July 2025
First Online: 7 October 2025
Competing interests
: A.M. and Y.E. (‘Immune system restoration by cell therapy’) have a pending US patent application (no. 18/043576), a pending EU patent application (no. 21863834.4) and a pending Israel patent application (no. 301045). A related specific aspect of the manuscript covered in this patent application is the emphasis on CD4-Eomes T cells as a potential biomarker of cellular senescence and treatment of aging and age-related diseases involving SC accumulation and immune system restoration. The other authors declare no competing interests.