Denk, Dominic https://orcid.org/0000-0002-4887-1492
Singh, Anurag
Kasler, Herbert G.
D’Amico, Davide https://orcid.org/0000-0002-8499-9514
Rey, Julia
Alcober-Boquet, Lucía https://orcid.org/0009-0009-9928-9388
Gorol, Johanna M.
Steup, Christoph https://orcid.org/0000-0001-6991-9910
Tiwari, Ritesh
Kwok, Ryan https://orcid.org/0000-0002-1850-6611
Argüello, Rafael J. https://orcid.org/0000-0001-9785-3883
Faitg, Julie
Sprinzl, Kathrin
Zeuzem, Stefan
Nekljudova, Valentina
Loibl, Sibylle
Verdin, Eric https://orcid.org/0000-0003-3703-3183
Rinsch, Chris
Greten, Florian R. https://orcid.org/0000-0002-3928-6080
Article History
Received: 3 November 2024
Accepted: 25 September 2025
First Online: 31 October 2025
Competing interests
: A.S., D. D’Amico and J.F. are employees, and C.R. is president and delegate of the board of Amazentis SA, which funded this clinical study and provided the investigational product (Mitopure). F.R.G. has received consulting fees from Amazentis. D. Denk has received travel compensation from Amazentis and AbbVie. There are restrictions to the commercial use of SCENITH due to a pending patent application (PCT/EP2020/WO2020212362A1 to R.J.A.). The remaining authors declare no competing interests related to this study.