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Authors
Chen, Qingwen https://orcid.org/0000-0002-2946-4947
Dwaraka, Varun B.
Carreras-Gallo, Natàlia
Armstrong, Jenel F.
Sehgal, Raghav https://orcid.org/0000-0002-9387-1758
Argentieri, M. Austin https://orcid.org/0000-0003-0242-853X
Richmond, Anne https://orcid.org/0000-0002-9504-510X
Aparicio, Andrea
Mendez, Kevin https://orcid.org/0000-0002-8832-2607
Chen, Yulu
Begum, Sofina
Kachroo, Priyadarshini
Prince, Nicole https://orcid.org/0000-0002-8506-1122
Guo, Tao https://orcid.org/0009-0005-8960-9203
Went, Hannah
Mendez, Tavis
Lin, Aaron
Turner, Logan
Moqri, Mahdi https://orcid.org/0000-0001-6675-0566
Chu, Su H.
Kelly, Rachel S. https://orcid.org/0000-0003-3023-1822
Weiss, Scott T.
Rattray, Nicholas J. W. https://orcid.org/0000-0002-3528-6905
Gladyshev, Vadim N. https://orcid.org/0000-0002-0372-7016
Karlson, Elizabeth
Wheelock, Craig E. https://orcid.org/0000-0002-8113-0653
Mathé, Ewy A.
Dahlin, Amber
McGeachie, Michael J. https://orcid.org/0000-0001-5566-2712
Marioni, Riccardo E. https://orcid.org/0000-0003-4430-4260
Higgins-Chen, Albert T. https://orcid.org/0000-0003-2904-2741
Smith, Ryan https://orcid.org/0000-0001-7362-8753
Lasky-Su, Jessica https://orcid.org/0000-0001-6236-4705
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Article History
Received: 27 November 2023
Accepted: 12 January 2026
First Online: 25 February 2026
Competing interests
: This work was completed under a sponsored research agreement between Brigham Women’s Hospital and TruDiagnostic. N.C.-G., L.B.D., I.G., R.D., D.P., A.T.H.-C., S.V., S.H., T.M., R. Sehgal and V.B.D. are employees of TruDiagnostic. J.L.-S. is a scientific advisor to TruDiagnostic, Precision and Ahara. R.E.M. is a scientific advisor to the Epigenetic Clock Development Foundation and Optima Partners. J.L.-S., Q.C., V.B.D. and R. Smith have filed patents on work from this publication. M.M. and V.N.G. have filed patents on measuring cellular aging. S.T.W. receives royalties from UpToDate and is on the Board of Histolix, a digital pathology company. R.E.M. is a scientific advisor to the Epigenetic Clock Development Foundation and Optima Partners. R. Sehgal is a scientific advisor for TruDiagnostic and has received consulting fees from the company. TruDiagnostic generated the DNAm and proteomic data. Investigators from TruDiagnostic co-analyzed and co-wrote the paper as described in the contributions above. The other authors declare no competing interests.
