Lan, Tammy C. T. https://orcid.org/0000-0003-0824-6796
Kochersberger, Alison
Raichur, Ruth https://orcid.org/0009-0005-9107-7357
Szady, Sophia
Tran, Hien
Simeonova, Radiana
Helmuth, Ashley https://orcid.org/0009-0000-6124-666X
Minagar, Andrew
Orozco Fuentes, Maria José
Kumar, Vipin
Marrero, Giovanni https://orcid.org/0000-0003-1587-3624
Barrera, Irving
Mangiameli, Sarah
Shalek, Alex K. https://orcid.org/0000-0001-5670-8778
Sabeti, Pardis C. https://orcid.org/0000-0002-9843-1890
Chen, Fei https://orcid.org/0000-0003-2308-3649
Fischer, David S. https://orcid.org/0000-0002-1293-7656
Garrison, Jennifer L.
Chung, Hattie https://orcid.org/0000-0001-8417-5606
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (R35 GM160070)
U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (R35 GM145305)
U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (R35 GM145305)
U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (R35 GM160070)
U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (R35 GM160070)
Yale University
Productive Health
Broad Institute (Eric and Wendy Schmidt Center fellowship)
Article History
Received: 5 March 2025
Accepted: 4 May 2026
First Online: 17 June 2026
Competing interests
: A.K.S. reports compensation for consulting and/or scientific advisory board membership from Honeycomb Biotechnologies, Cellarity, Danaher, Ochre Bio, Bio-Rad Laboratories, Relation Therapeutics, IntrECate biotherapeutics, Parabalis Medicines, Passkey Therapeutics and Dahlia Biosciences unrelated to this work. P.C.S. is a co-founder of Sherlock Biosciences and Delve Biosciences, a board member of Polaris Genomics, a former board member of Danaher Corporation and a former scientific advisory board member of NextJenGane and holds equity in the companies unrelated to this work. F.C. is a founder of Curio Bioscience and Doppler Bio. J.L.G. is a scientific advisory board member of WndrHlth, Era Women’s Health and House of Innovation, a former scientific advisory board member of Evernow and a founder of Stealth Bio and holds equity in companies unrelated to this work. The other authors declare no competing interests.