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Authors
Abbasi, Ali B.
Liu, Kathleen D.
Russell, Derek W. https://orcid.org/0000-0002-2716-1344
Files, D. Clark
Thomas, Karl W.
Yousef, Fady
Gandotra, Sheetal https://orcid.org/0000-0002-5475-9704
Discacciati, Andrea
Lim, Noha
Asare, Adam L.
Eklund, Martin https://orcid.org/0000-0001-5032-5266
Matthay, Michael https://orcid.org/0000-0003-3039-8155
Esserman, Laura J. https://orcid.org/0000-0001-9202-4568
,
Aggarwal, Neil R.
Burnham, Ellen L.
Higgins, Carrie
McKeehan, Jeff
Albertson, Timothy
Haczku, Angela
Hardy, Erin
Harper, Richart
Morrissey, Brian
Sandrock, Christian
Auld, Sara
Yang, Philip
Detelich, Joshua
Harris, Gavin
Nugent, Katherine
Adelman, Max
Beitler, Jeremy R.
Darmanian, Anita
Dzierba, Amy L.
Garcia, Ivan
Gosek, Katarzyna
Madahar, Purnema
Mittel, Aaron M.
Muir, Justin
Rosen, Amanda
Schicchi, John
Serra, Alexis L.
Wahab, Romina
Berger, Paul
Calfee, Carolyn S.
Coleman, Melissa
Jauregui, Alejandra
Cobb, Nathan
Sonti, Rajiv
Hamed, Amen M.
Crippa, Alessio
Discacciati, Andrea
Eklund, Martin
Esserman, Laura
Files, D. Clark
Thomas, Karl
Gibbs, Kevin W.
Landreth, Leigha
LaRose, Mary
Parks, Lisa
Wynn, Adina
Friedman, Eliot
Russell, Derek W.
Harris, Donna
Methukupally, Abhishek
Patel, Siddharth
Gandotra, Sheetal
Khan, Kashif
Wong, Se Fum
Yen, Albert
Koff, Jonathan
Boerger, Lindsie
Kazianis, John
Kumar, Santhi
Liu, Kathleen D.
Martin, Thomas R.
Wurfel, Mark M.
Matthay, Michael A.
Daniel, Brian
Meyer, Nuala J.
Ittner, Caroline A. G.
Mangalmurti, Nilam S.
Reilly, John P.
Obermiller, Timothy
Robinson, Philip A.
Sarafian, Farjad
Shah, Usman
Wunderink, Richard G.
Budinger, G. R. Scott
Donnelly, Helen K.
Singer, Benjamin D.
Youssef, Fady A.
Belvins, Daniel
Nguyen, Catherine
Suarez, Alexis
Tanios, Maged A.
Fields, Scott
Hurst-Hopf, James
Swigart, Lamorna Brown
Creel-Bulos, Christina
Spainhour, Christina
Moskowitz, Ari
Vijhani, Praveen
Casciato, Adrienne M.
Capetillo, Vaney
Wei, Kenenth
Huynh, Tracie
Rodriguez-Vasquez, Anna
Nates, Joseph L.
Suarez, Jessica
Nair, Siddharth
Samavedam, Sandya
Bernstein, Michael
Jordan, Christopher
Kett, Daniel H.
Escalona, Karla Leon
Lee, Richard A.
Remy, Kenneth
Zarrinpar, Ali
Hyzy, Robert
Nelson, Kristine
Quill, Caroline
Mazza, Emilio
Broderick, Kristin
Hayanga, Jermiah
Monteiro, Ana Costa
Levitt, Joseph
Lu, Ruixiao
Henderson, Paul
Asare, Adam
Dunn, Imogene
Barragan, Alejandro Botello
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Funding
Funding for this research was provided by:
U.S. Department of Health & Human Services | Biomedical Advanced Research and Development Authority
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Article History
Received: 4 December 2024
Accepted: 2 September 2025
First Online: 29 October 2025
Competing interests
: The authors declare the following competing interests: Ali B. Abbasi reports meeting travel reimbursements from Duke Clinical Research Institute and Johnson & Johnson. Kathleen D. Liu is an employee of the study sponsor, Quantum Leap Healthcare Collaborative, has received consulting fees from Baxter, Seastar Biomedical, AM Pharma, Biomerieux and UpToDate, acts in a paid advisory role to BOA Medical and Novartis, and holds securities in Amgen. Derek W. Russell received support from NIH Grant K08HL148514, grants from ABSS Solutions, Inc., the CHEST Foundation, and the NHLBI Prevention and Early Treatment of Lung Injury PETAL Network. He acts in an advisory capacity to Direct Biologics, Inc., and holds securities in Achieve Life Sciences. D. Clark Files has received consulting fees from Global Blood Therapeutics and Direct Biologics. Karl W. Thomas has received royalties from UpToDate, payments for expert testimony from Lewisbrisbois, Rushton, Stakey, Kohnston & Garrett PA and Phelan Tucker Law LLP, and holds securities in Bristol-Myers Squibb, Doximity, Gilead Sciences Inc, Johnson & Johnson and Pfizer. Fady Yousef has received payments for expert testimony from Independent Medical Examination and is a paid member of DSMB for Wuhan AltaScience. Martin Eklund has received consultancy fees from the study sponsor Quantum Leap Healthcare Collaborative, honoraria from Ipsen and Janssen, and holds securities in A3P Biomedical AB and Clinsight AB. Laura J. Esserman is a Medical Advisory Panel member for Blue Cross Blue Shield, sits on the board of directors of the study sponsor, Quantum Leap Healthcare Collaborative, and has received consulting fees from UpToDate. All other authors have nothing to disclose. Quantum Leap Healthcare Collaborative (QLHC) is a 501(c)3 not for profit organization and sponsor of the I-SPY COVID trial. QLHC provided a range of services to support the study, including all data and safety management, regulatory functions, and fundraising. For this manuscript, QLHC provided all relevant data, but played no part in drafting its content or conclusions.
