Lei, Ienglam https://orcid.org/0000-0002-0248-6871
Sicim, Hüseyin https://orcid.org/0000-0003-3430-3862
Gao, Wenbin https://orcid.org/0000-0001-9268-8823
Huang, Wei
Noly, Pierre Emmanuel
Pergande, Melissa R.
Wilson, Mallory C.
Lee, Aurora https://orcid.org/0009-0000-4607-5188
Liu, Liu
Abou El Ela, Ashraf
Jiang, Mulan
Saddoughi, Sahar A.
Pober, Jordan S. https://orcid.org/0000-0001-5990-1071
Platt, Jeffrey L.
Cascalho, Marilia https://orcid.org/0000-0002-2695-3921
Pagani, Francis D. https://orcid.org/0000-0003-4430-9969
Chen, Y. Eugene https://orcid.org/0000-0003-2357-7825
Pitt, Bertram
Wang, Zhong
Mortensen, Richard M.
Ge, Ying
Tang, Paul C. https://orcid.org/0000-0003-4211-8587
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (HL164416, HL166140, HL159871, HL134569, HL109946, HL163672, HL139735, HL109810)
American Heart Association (930124)
U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (GM135119)
U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (U01-AI132895, AI151588, AI173950, AI151588, AI173950)
Article History
Received: 18 March 2024
Accepted: 11 April 2025
First Online: 19 May 2025
Competing interests
: I.L., Z.W., F.D.P., B.P., Y.E.C. and P.C.T. have filed a US provisional patent (title: Histone-acetylation-modulating agents for the treatment and prevention of organ injury, no. 63/045,784, international application no. PCT/US2021/039650). A.A.E.E. has a consulting agreement with TransMedics. F.D.P. is an ad hoc, noncompensated scientific advisor for Medtronic, Abbott, FineHeart and CH Biomedical and a noncompensated medical monitor for Abiomed. F.D.P. is also a member of the data safety monitoring board for Carmat and the NHLBI PumpKIN clinical trial as well as the chair of data safety and management for the DCD heart national FDA clinical trial and the EXPAND heart-Continuous access protocol national FDA trial. P.C.T. is a noncompensated member of the data safety monitoring board for the XVIVO Perfusion PRESERVE trial. The other authors declare no competing interests.