Rjoob, Khaled
McGurk, Kathryn A. https://orcid.org/0000-0002-5445-6906
Zheng, Sean L. https://orcid.org/0000-0002-5762-6392
Curran, Lara
Ibrahim, Mahmoud
Zeng, Lingyao
Kim, Vladislav
Tahasildar, Shamin https://orcid.org/0009-0000-1463-9997
Kalaie, Soodeh
Senevirathne, Deva S.
Gifani, Parisa
Losev, Vladimir https://orcid.org/0000-0001-9677-7022
Zheng, Jin
Bai, Wenjia https://orcid.org/0000-0003-2943-7698
de Marvao, Antonio https://orcid.org/0000-0001-9095-5887
Ware, James S. https://orcid.org/0000-0002-6110-5880
Bender, Christian https://orcid.org/0000-0003-2630-1453
O’Regan, Declan P. https://orcid.org/0000-0002-0691-0270
Funding for this research was provided by:
RCUK | Medical Research Council (MC_UP_1605/13)
British Heart Foundation (RG/F/24/110138)
British Heart Foundation (RE/24/130023)
British Heart Foundation (CH/F/24/90015)
British Heart Foundation (BBC/F/21/220106)
British Heart Foundation (FS/IPBSRF/22/27059)
Bayer
DH | National Institute for Health Research
Sir Jules Thorn Charitable Trust (21JTA)
Article History
Received: 22 July 2025
Accepted: 10 November 2025
First Online: 29 December 2025
Competing interests
: D.P.O’R. receives research support from Bayer AG and Calico Labs, and is a paid consultant to Bayer AG and Bristol Myers Squibb. J.S.W. has received research support from Bristol Myers Squibb, has acted as a paid advisor to Health Lumen, Tenaya Therapeutics, and Solid Biosciences, and is a founder with equity in Saturnus Bio. All other authors declare no competing interests.