Jadiya, Pooja
Berezhnaya, Elena
Kolmetzky, Devin W
Tomar, Dhanendra
Cohen, Henry M https://orcid.org/0000-0002-2172-2008
Shukla, Shatakshi
Thomas, Manfred
Khaledi, Salman
Garbincius, Joanne F https://orcid.org/0000-0002-4334-6445
Kennedy, Liam https://orcid.org/0009-0003-2372-3447
Salik, Oniel
Raghav, Darpan
Hildebrand, Alycia N
Elrod, John W https://orcid.org/0000-0003-3925-2224
Funding for this research was provided by:
HHS | NIH | National Institute of Neurological Disorders and Stroke (R01NS121379)
HHS | NIH | National Heart, Lung, and Blood Institute (P01HL147841)
HHS | NIH | National Heart, Lung, and Blood Institute (P01HL134608)
HHS | NIH | National Heart, Lung, and Blood Institute (R01HL136954)
HHS | NIH | National Heart, Lung, and Blood Institute (R01HL142271)
HHS | NIH | National Heart, Lung, and Blood Institute (3R01HL123966-05S1)
HHS | NIH | National Heart, Lung, and Blood Institute (F32HL151146)
American Heart Association (20EIA35320226)
American Heart Association (24IPA1273195)
Pennsylvania Department of Health (420792)
HHS | NIH | National Institute on Aging (K99AG065445)
HHS | NIH | National Institute on Aging (F30AG082407)
Alzheimer's Association (24AARG-D-1191292)
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (K99DK120876)
WFU | WFSM | Alzheimer's Disease Research Center, Wake Forest School of Medicine (P30AG072947)
Article History
Received: 10 October 2023
Revised: 26 February 2026
Accepted: 27 April 2026
First Online: 22 May 2026
Disclosure and competing interests statement
: The authors have no financial conflict of interest to report. Readers are welcome to comment on the online version of the paper. The graphical schematic was created with assistance from ChatGPT (OpenAI); all scientific content and interpretation and editing are the authors with no other use of AI. Correspondence and requests for materials should be addressed to JWE (elrod@temple.edu).