Acin-Perez, Rebeca https://orcid.org/0000-0001-9553-8337
Assali, Essam A https://orcid.org/0000-0002-7788-7047
Veliova, Michaela https://orcid.org/0000-0003-1117-691X
Ngo, Jennifer https://orcid.org/0000-0002-5829-6866
Brownstein, Alexandra J https://orcid.org/0000-0003-0920-722X
Villalobos, Francisco
Petcherski, Anton https://orcid.org/0000-0002-3143-3867
Hernansanz-Agustin, Pablo https://orcid.org/0000-0003-2935-207X
Kim-Vasquez, Doyeon https://orcid.org/0009-0001-4843-9798
Xu, Shili
Tamboline, Mikayla
Silva, Raquel Maria
Upcher, Alexander https://orcid.org/0000-0002-0910-6552
Shu, Cynthia https://orcid.org/0000-0001-8215-2195
Ferriss, Daniel E https://orcid.org/0009-0002-2451-4623
Liesa, Marc https://orcid.org/0000-0002-5909-8570
Enriquez, Jose Antonio https://orcid.org/0000-0002-3671-2961
Sekler, Israel https://orcid.org/0000-0002-7550-1550
Shirihai, Orian S https://orcid.org/0000-0001-8466-3431
Funding for this research was provided by:
Israel Science Foundation (1424/17,DIP SE 2372/1-1)
Ministerio de Ciencia e Innovación (MCIN/AEI/10.13039/501100011033)
Ministerio de Ciencia e Innovación (PID2021-127278NB-I00)
ERDF (EU grant ERDF A)
BBVA | Fundación BBVA (Beca Leonardo LEO22-2-1659-BBM-BIO-18)
HHS | National Institutes of Health (DDRC NIH-NIDDK P30 DK041301)
HHS | National Institutes of Health (UCLA/UCSD DERC NIH-NIDDK: P30 DK063491)
HHS | National Institutes of Health (R01 DK099618-05)
HHS | National Institutes of Health (R01 CA232056-01)
HHS | National Institutes of Health (R21AG060456-01)
HHS | National Institutes of Health (R21 AG063373-01)
American Diabetes Association (ADA Grant No. 1-19-IBS-049)
UC | UCLA | David Geffen School of Medicine, University of California, Los Angeles (Seed award from DGSOM)
Article History
Received: 17 August 2025
Revised: 19 May 2026
Accepted: 21 May 2026
First Online: 3 July 2026
Disclosure and competing interests statement
: AP, ML and OSS are co-founders and consultants of Enspire Bio LLC. AP and OSS are co-founders and OSS is SAB member of Senergy-Bio and Capacity-Bio, and when this study was conducted, he served as a consultant to LUCA-Science, IMEL, Epirium, Johnson & Johnson, Pfizer and Stealth Biotherapeutics.