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Nakayama, Chihiro https://orcid.org/0009-0000-7081-6222

Fang, Qi https://orcid.org/0009-0009-5296-1843

Daigaku, Yasukazu https://orcid.org/0000-0002-8404-7492

Aoi, Yuki https://orcid.org/0000-0002-0252-9536

Ito, Shoko https://orcid.org/0000-0002-2797-4177

Takahashi, Mami

Shimatani, Reo

Minamisawa, Tamiko

Ozturk, Yagiz https://orcid.org/0009-0004-4351-7410

Kimura, Hiroshi https://orcid.org/0000-0003-0854-083X

Shilatifard, Ali https://orcid.org/0000-0002-7490-2854

Tellier, Michael https://orcid.org/0000-0002-4130-9050

Nojima, Takayuki https://orcid.org/0000-0003-1236-4162

Funding for this research was provided by:

Royal Society (ICA\R1\231018)

Royal Society (ICA\R1\231018)

Ministry of Education, Culture, Sports, Science and Technology (JP19K24692)

Ministry of Education, Culture, Sports, Science and Technology (JP24K01957)

Ministry of Education, Culture, Sports, Science and Technology (JP23H02463)

MEXT | JST | Fusion Oriented REsearch for disruptive Science and Technology (JPMJFR2050)

MEXT | JST | Fusion Oriented REsearch for disruptive Science and Technology (JPMJFR204X)

UKRI | Medical Research Council (MR/W007002/1)

Astellas Foundation for Research on Metabolic Disorders (na)

Daiichi Sankyo Foundation of Life Science (na)

The Ichiro Kanehara Foundation for Promotion of Medical Sciences and Medical Care (na)

The Mitsubishi Foundation (na)

The Mochida Memorial Foundation for Medical and Pharmaceutical Research (na)

The Naito Foundation (na)

The NOVARTIS Foundation (Japan) for the Promotion of Science (na)

Princess Takamatsu Cancer Research Fund (na)

The Shinnihon Foundation of Advanced Medical Treatment Research (na)

The Sumitomo Foundation (na)

The Uehara Memorial Foundation (na)

Yamada Science Foundation (na)

University of Leicester F50 PhD studentship (na)

HHS | National Institutes of Health (R35CA197569)

MEXT | JST | Support for Pioneering Research Initiated by the Next Generation (JPMJSP2136)

RIKAKEN HD (na)

MEXT | Japan Society for the Promotion of Science (JP25KJ1964)

MEXT Cooperative Research Project Program, Medical Research Center Initiative for High Depth Omics, and CURE (JPMXP1323015486)

Text and Data Mining valid from 2026-02-20

Version of Record valid from 2026-02-20