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Authors
Kawamoto, Shimpei https://orcid.org/0000-0002-7033-671X
Horiguchi, Haruki https://orcid.org/0000-0001-9344-8362
Torigoe, Daisuke https://orcid.org/0009-0007-9924-4994
Wakita, Masahiro
Ito, Koyu
Sugawara, Sho https://orcid.org/0000-0003-0010-7409
Zhou, Xiangyu
Mikawa, Takumi https://orcid.org/0000-0003-0980-2379
Park, Jeong Hoon
Jung, Birte Kristin
Okumura, Yumiko
Miyagawa, Hideka
Maruya, Mikako
Hori, Nozomi
Uemura, Ken
Sugimoto, Masataka https://orcid.org/0000-0001-8737-8097
Matsuda, Michiyuki https://orcid.org/0000-0002-5876-9969
Mochizuki, Naoki https://orcid.org/0000-0002-3938-9602
Kondoh, Hiroshi https://orcid.org/0000-0002-1067-2244
Takahashi, Akiko https://orcid.org/0000-0003-1904-7645
Oike, Yuichi
Hara, Eiji https://orcid.org/0000-0001-7821-3960
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Funding
Funding for this research was provided by:
Japan Agency for Medical Research and Development (JP24gm1710004h0003)
Japan Agency for Medical Research and Development (JP25zf0127008h0002)
MEXT | JSPS | Japan Society for the Promotion of Science (JP25H00443)
MEXT | JSPS | Japan Society for the Promotion of Science (JP23K06481)
MEXT | Japan Science and Technology Agency (JPMJFR2308)
MEXT | Japan Science and Technology Agency (JP24gm1710001h0003)
MEXT | Japan Science and Technology Agency (JPMXP1323015484)
OU Master Plan Implementation Project under the University of Osaka
Takeda Science Foundation
Lotte Foundation
Nagase Science Technology Foundation
Mitsubishi Foundation
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Article History
Received: 14 May 2025
Revised: 22 January 2026
Accepted: 13 February 2026
First Online: 3 April 2026
Disclosure and competing interests statement
: MS is a co-author of the Science paper (Science. 2021 Jan 15;371(6526):265–270), which is critically discussed in the present manuscript. In that study, MS’s contribution was limited to administering the GLS1 inhibitor to aged mice. In the present study, MS provided technical advice on GLS1 inhibitor administration based on his prior experience. MS was not involved in the design, execution, or interpretation of the phenotypic or molecular analyses in either study. The other authors declare no competing interests.
