Hori, Nozomi
Kawamoto, Shimpei https://orcid.org/0000-0002-7033-671X
Uemura, Ken
Kinugasa-Katayama, Yumi
Okumura, Yumiko
Tanaka, Kentaro
Park, Jeong Hoon
Wakita, Masahiro
Motooka, Daisuke
Ohtani, Naoko
Hara, Eiji https://orcid.org/0000-0001-7821-3960
Funding for this research was provided by:
Japan Agency for Medical Research and Development (JP21gm5010001h0005)
Japan Agency for Medical Research and Development (JP25gm1710004h0004)
Japan Agency for Medical Research and Development (JP25zf0127008h0004)
Japan Agency for Medical Research and Development (JP24gm4010026)
Japan Agency for Medical Research and Development (JP24ck0106793)
MEXT | Japan Science and Technology Agency (JPMJMS2022)
MEXT | Japan Science and Technology Agency (JPMJFR2308)
MEXT | Japan Science and Technology Agency (JPMJFR2308)
MEXT | JSPS | Japan Society for the Promotion of Science London (JP25H00443)
MEXT | JSPS | Japan Society for the Promotion of Science London (JP23K06481)
MEXT | JSPS | Japan Society for the Promotion of Science London (JP22H03540)
Mitsubishi Foundation (202012016)
Nagase Science and Technology Foundation (B-306)
Princess Takamatsu Cancer Research Fund (23-255011)
Lotte Foundation (2025A0006)
Astellas Foundation for Research on Metabolic Disorders (2025A1138)
Chugai Foundation for Innovative Drug Discovery Science (2025-S22-03)
Takeda Science Foundation (Visionary Start 2024096877)
Takeda Science Foundation (Visionary Step 2023149857)
Ministry of Education, Culture, Sports, Science and Technology (JPMXP1323015484)
Article History
Received: 20 August 2025
Revised: 26 March 2026
Accepted: 30 March 2026
First Online: 28 May 2026
Disclosure and competing interests statement
: NO and EH are co-authors of Demaria et al (Developmental Cell. 2014 Dec 22; 31:722-733). However, neither NO nor EH conducted any experiments using the p16-3MR mouse model in that study. All remaining co-authors declare no conflicts of interest.