Zhao, Yu-Long https://orcid.org/0009-0009-9091-8766
Zhao, Yi-Ming https://orcid.org/0009-0005-3462-6524
Yan, Yi-Fang https://orcid.org/0000-0002-3506-2653
Yang, Ning https://orcid.org/0009-0000-3329-8657
Ma, Si-Nan https://orcid.org/0009-0005-1193-4882
Wang, Rui-Jia
Feng, Gui-Hai https://orcid.org/0000-0002-8726-1734
Li, Zhi-Kun https://orcid.org/0000-0002-0542-2339
Li, Wei https://orcid.org/0000-0001-7864-404X
Wang, Li-Bin https://orcid.org/0000-0002-2462-5342
Funding for this research was provided by:
北京市科学技术委员会 | Natural Science Foundation of Beijing Municipality (7242083)
北京市科学技术委员会 | Natural Science Foundation of Beijing Municipality (Z230011)
MOST | National Natural Science Foundation of China (32470910)
MOST | National Natural Science Foundation of China (32225030)
national health commission key laboratory of birth defects prevention (NHCKLBDP202409)
Ministry of Science and Technology of the People's Republic of China (2022YFA1103600)
Ministry of Science and Technology of the People's Republic of China (2024YFA0917403)
Article History
Received: 10 June 2025
Revised: 16 December 2025
Accepted: 2 January 2026
First Online: 15 January 2026
Disclosure and competing interests statement
: The authors declare no competing interests.