Costa, Daniela G
Gee, Lucy M
Lee, Gung
Sales Gomez, Lilian https://orcid.org/0000-0002-5309-7438
Franco, Ana Catarina https://orcid.org/0000-0001-6730-7021
Vizioli, Maria Grazia
Valdivieso, Karla https://orcid.org/0000-0002-8058-5453
Zhang, Lei J https://orcid.org/0000-0001-7409-6090
Pirius, Nick
Martini, Helene https://orcid.org/0000-0001-8789-4585
Porritt, Rebecca A
Saul, Dominik https://orcid.org/0000-0002-0673-3710
Cavadas, Claudia https://orcid.org/0000-0001-8020-9266
Ebert, Scott https://orcid.org/0000-0002-6598-2629
LeBrasseur, Nathan K https://orcid.org/0000-0002-2002-0418
Khosla, Sundeep https://orcid.org/0000-0002-2936-4372
Passos, João F https://orcid.org/0000-0001-8765-1890
Adams, Christopher M
Robbins, Paul D https://orcid.org/0000-0003-1068-7099
Jurk, Diana https://orcid.org/0000-0003-4486-0857
Funding for this research was provided by:
HHS | NIH | National Institute on Aging (AG068182)
HHS | NIH | National Institute on Aging (AG062413)
HHS | NIH | National Institute on Aging (AG079754)
HHS | NIH | National Institute on Aging (AG076041)
HHS | NIH | National Institute on Aging (AI172501)
HHS | NIH | National Institute on Aging (AG086085)
HHS | NIH | National Institute on Aging (R01AG068048)
HHS | NIH | National Institute on Aging (R01AG82708)
HHS | NIH | National Institute on Aging (U19 AG056278)
Hevolution Foundation (#A22001)
Hevolution Foundation (P30DK084567)
Article History
Received: 4 November 2025
Revised: 23 February 2026
Accepted: 25 February 2026
First Online: 1 April 2026
Disclosure and competing interests statement
: CMA is an inventor on patents for the use of tomatidine in muscle health and metabolic health, which are licensed to Emmyon, Inc., where CMA and SME are shareholders and officers.