Toyama, Kensuke
Koibuchi, Nobutaka
Hasegawa, Yu
Uekawa, Ken
Yasuda, Osamu
Sueta, Daisuke
Nakagawa, Takashi
Ma, Mingjie
Kusaka, Hiroaki
Lin, Bowen
Ogawa, Hisao
Ichijo, Hidenori
Kim-Mitsuyama, Shokei
Article History
Received: 16 January 2015
Accepted: 5 May 2015
First Online: 5 June 2015
Change Date: 9 July 2015
Change Type: Update
Change Details: This Article was originally published under the license text for CC BY-NC-ND 4.0., which has now been changed to CC BY 4.0. The PDF and HTML versions of the paper have been modified accordingly.
Change Date: 8 October 2015
Change Type: Update
Change Details: A correction has been published and is appended to both the HTML and PDF versions of this paper. The error has been fixed in the paper.
Change Date: 8 October 2015
Change Type: Erratum
Change Details: Although high-fat diet intake is known to cause obesity and diabetes, the effect of high-fat diet itself on cognitive function remains to be clarified. We have previously shown that apoptosis signal-regulating kinase 1 (ASK1) is responsible for cognitive impairment caused by chronic cerebral hypoperfusion. The present work, by using ASK1 deficient mice, was undertaken to explore the influence of chronic high-fat diet intake on cognitive function and the role of ASK1. Cognitive function in wild-type mice fed high-fat diet from 2 to 24 months of age was significantly impaired compared to those fed control diet, which was associated with the significant white matter lesions, reduction of hippocampal capillary density, and decrement of hippocampal neuronal cell. However, ASK1 deficiency abolished the development of cognitive impairment and cerebral injury caused by high-fat diet. Our results provided the evidence that high-fat diet itself causes cognitive impairment and ASK1 participates in such cognitive impairment.
Competing interests
: The authors declare no competing financial interests.