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Article History
Received: 19 October 2014
Revised: 5 December 2014
Accepted: 8 January 2015
First Online: 17 March 2015
Competing interests
: Celine Bellenguez received personal fees from Genoscrenn unrelated to current study. HS reports grants from Austrian Science Fond (FWF) and Österreichische Nationalbank Anniversary Fund during the conduct of the study. FP reports grants from DISTALZ Labex of Excellence (ANR). NF reports payment from Janessen Alzheimer’s Immunotherapty and Pfizer to University College London for contracted image analyses and payment from Bristol Myers Squibb, Eli Lilly, GE Healthcare, Novartis and Sanofi to University College London for consultant services. JH received personal fees from Eisai, Eli Lilly and Roche, outside the current study. AMG received grants from NIA, Genentech, Pfizer and Astra Zeneca, as well as personal fees from Finnegan HC, Cognition Therapeutics, Dickstein Shapiro, Genentech and Amgen, all unrelated to the current study. In addition, AMG has a patent (US20070258898) issued and a patent with royalties paid by Taconic. WM received grants from Eli Lilly and Lundbeck. J-FD received grants and personal fees from IPSEN and Novartis and personal fees from Newron. HH reports personal fees and non-financial support from Boehringer-Ingelheim, Bristol-Myers-Squibb, Elan Corporation, Novartis, Eisai Inc., Pfizer, Sanofi-Aventis, Roche Pharmaceutical Diagnostics, GlaxoSmithKline-Biologicals, Jung-Diagnostics, Avid, Eli Lilly and Cytox and personal fees from GE Healthcare. In addition, HH has pending patents entitled ‘Method for predicting whether subjects with mild cognitive impairment (MCI) will develop Alzheimer's disease’, ‘3-Hydroxykynurenin im Serum als diagnostischer Marker fUr die Demenz vom Alzheimer-Typ’, ‘Neurodegenerative markers for psychiatric conditions’, ‘Ratio A~2/40 im Plasma in der Fruh- und Differentialdiagnose der Alzheimer Krankheit’, Liquordiagnostisches in vitro Verfahren zur Diagnose von Demenz-ErkrankUngen und neuroinfJammatorischen Erkrankungen’, ‘In vitro Verfahren zur Diagnose von neurodegenerativen Erkrankungen’ and ‘In vitro Verfahren zur Diagnose und Fruhdiagnose von neurodegenerativen Erkrankungen’. EBL received personal fees from Up to Date unrelated to the current study. MO received research grants from the Medical Research Council during the course of, but unrelated to, the current study. EMR received personal fees from AstraZeneca, CereSpir, Eisai, Eli Lilly, GlaxoSmithKline and Sanofi and research contracts from Avid/Eli Lilly and Genetech, all unrelated to the current study. JW is a full-time employee and shareholder of Pfizer (2012–present) and a former full-time employee of F. Hoffmann-La Roche (2010–2012). AW is a full-time employee and shareholder of Pfizer (2013–present). MAP-V received personal fees from Athena Neurosciences unrelated to the current study. The other authors declare no conflict of interest.