Lau, On-Chai
Shen, Bing
Wong, Ching-On
Tjong, Yung-Wui
Lo, Chun-Yin
Wang, Hui-Chuan
Huang, Yu
Yung, Wing-Ho
Chen, Yang-Chao
Fung, Man-Lung
Rudd, John Anthony
Yao, Xiaoqiang
Article History
Received: 11 March 2015
Accepted: 13 May 2016
First Online: 14 July 2016
Change Date: 23 March 2018
Change Type: Update
Change Details: A correction to this article has been published and is linked from the HTML version of this article. It has come to our attention that errors were made in measurements of resting blood pressure reported in this Article, in Figure 8 and in the Results section entitled ‘Deficiency of baroreceptor function in Trpc5 knockout (<i>Trpc5</i><sup><i>−/−</i></sup>) mice’. Two of the twelve measurements for <i>Trpc5</i><sup><i>−/−</i></sup> mice exceeded physiologically realistic values (277.3 and 390.5 mm Hg), and we assume were a result of technical errors in blood pressure recording. Upon removal of these two outliers and their corresponding control measurements, and replacement with resting blood pressure measurements from two additional pairs of mice, we no longer find a statistically significant difference in the resting mean arterial pressure between <i>Trpc5</i><sup><i>−/−</i></sup> and wild-type mice. We can therefore no longer conclude that <i>Trpc5</i> knockout increases basal blood pressure. However, a statistically significant difference in range of blood pressure variation over 24 h remains. These errors therefore do not affect our conclusion that <i>Trpc5</i> knockout results in blood pressure instability. An updated version of Figure 8d which includes the above data is presented in the associated Author Correction as Figure 1. The error has not been corrected in the original version of the Article. Furthermore, all resting mean arterial blood pressure data from the two mouse cohorts are presented as Supplementary Data 1 associated with the Author Correction.
Competing interests
: The authors declare no competing financial interests.