Received: 16 September 2019
Revised: 20 January 2020
Accepted: 11 February 2020
First Online: 21 February 2020
Compliance with ethical standards
: The authors declare that they have no conflict of interest.
: Human blood samples were obtained upon written informed consent (Ethics Committee Salzburg approval: 415-E/1287/4—2011, 415-E/1287/13—2016) from CLL patients at the Department of Internal Medicine III, Paracelsus Medical University, Salzburg, Austria. All mouse experiments were performed under the approval of the Austrian or German Animal Ethics Committee (BMWF-66.012/0030-II/3b/2013, BMWF-66.012/0009-II/3b/2012, 20901-TVG/52/11—2012, 20901-TVG/89/7—2014, BMBWF-66.012/0002-V/3b/2018, G18/155).