Larson, Richard A. http://orcid.org/0000-0001-9168-3203
Mandrekar, Sumithra J.
Huebner, Lucas J.
Sanford, Ben L.
Laumann, Kristina
Geyer, Susan
Bloomfield, Clara D. http://orcid.org/0000-0001-5465-7591
Thiede, Christian
Prior, Thomas W.
Döhner, Konstanze
Marcucci, Guido http://orcid.org/0000-0002-3983-5908
Voso, Maria Teresa http://orcid.org/0000-0002-6164-4761
Klisovic, Rebecca B.
Galinsky, Ilene
Wei, Andrew H. http://orcid.org/0000-0002-7514-3298
Sierra, Jorge
Sanz, Miguel A. http://orcid.org/0000-0003-1489-1177
Brandwein, Joseph M.
de Witte, Theo
Niederwieser, Dietger http://orcid.org/0000-0002-4737-1103
Appelbaum, Frederick R. http://orcid.org/0000-0002-1839-5069
Medeiros, Bruno C. http://orcid.org/0000-0001-6972-8137
Tallman, Martin S.
Krauter, Jürgen
Schlenk, Richard F. http://orcid.org/0000-0003-2215-2059
Ganser, Arnold
Serve, Hubert
Ehninger, Gerhard
Amadori, Sergio
Gathmann, Insa
Döhner, Hartmut
Stone, Richard M.
Funding for this research was provided by:
U.S. Department of Health & Human Services | NIH | National Cancer Institute (U10CA180821, U10CA180882, U24CA198171)
U.S. Department of Health & Human Services | NIH | National Cancer Institute
U.S. Department of Health & Human Services | NIH | National Cancer Institute
Novartis
Article History
Received: 27 September 2020
Revised: 13 January 2021
Accepted: 1 February 2021
First Online: 2 March 2021
Compliance with ethical standards
:
: RAL has acted as a consultant or advisor to Novartis, Amgen, Ariad/Takeda, Astellas, Celgene/BMS, CVS/Caremark, Epizyme, and MorphoSys, and has received clinical research support from Novartis, Astellas, Celgene, Cellectis, Daiichi Sankyo, Forty Seven, Rafael Pharmaceuticals, and royalties from UpToDate. SJM has acted as a consultant or advisor for Pfizer and Pique Therapeutics, and has another relationship with BeiGene. CT is the Chief Executive Officer and a co-owner of AgenDix, a company performing molecular diagnostics, and has acted as a consultant or advisor for Novartis and Astellas, and has received clinical research support from Bayer. KD has acted as a consultant or advisor for Astellas, Celgene, Daiichi Sankyo, Janssen, Novartis, and Roche and has received clinical research support from Astex, Celgene, and Novartis. GM, RBK, DN, and HS have acted as consultants or advisors for Novartis. AHW has acted as a consultant or advisor for Novartis, Astellas, Pfizer, MacroGenics, AbbVie, Genentech, Servier, Celgene, Amgen, Astra Zeneca, and Janssen, and is a member of the speakers bureau for AbbVie/Genentech and Novartis, and has received research funding from Novartis, Celgene, AbbVie, Servier, Astra Zeneca, and Amgen, and is a former employee of the Walter and Eliza Hall Institute and receives a fraction of its royalty stream related to venetoclax. JS has acted as a consultant or advisor for Pfizer, Daiichi Sankyo, AbbVie, Novartis, Astellas, and Roche and is a member of the speakers bureau for Novartis, Pfizer, Daiichi Sankyo, and AbbVie. MAS has acted as a consultant or advisor for Teva Pharmaceutical Industries, Daiichi Sankyo, Orsenix, AbbVie, Novartis, and Pfizer. TdW has acted as a consultant or advisor for Novartis, Celgene, Johnson & Johnson, and Incyte and has received clinical research support from Novartis, Celgene, and Johnson & Johnson. BCM has acted as a consultant or advisor for Celgene, Novartis, and Astellas and is currently employed by Roche/Genentech. MST has acted as a consultant or advisor for AbbVie, BioLineRx, Daiichi Sankyo, Orsenix, KAHR Medical, Rigel Pharmaceuticals, Nohla, Delta Fly Pharma, Tetraphase, Oncolyze, and Jazz Pharmaceuticals, and has received clinical research funding from AbbVie, Cellerant Therapeutics, Orsenix, ADC Therapeutics, and BioSight, and has received royalties from UpToDate. JK has acted as a consultant or advisor for Amgen, Astellas, Bristol-Myers Squibb, Daiichi Sankyo, and Pfizer. AG has received clinical research support from Novartis. RFS has acted as a consultant or advisor for Pfizer and Daiichi Sankyo, is a member of the speakers bureau for Novartis, Pfizer, and Daiichi Sankyo, and has received clinical research funding from Pfizer, Daiichi Sankyo, PharmaMar, Astra Zeneca, and Roche. SA has acted as a consultant or advisor for Novartis and Daiichi Sankyo. IGathmann is an employee of Novartis. HD has acted as a consultant or advisor for AbbVie, Agios, Amgen, Astellas, Astex Pharmaceuticals, Celgene, Helsinn, Janssen, Jazz Pharmaceuticals, Novartis, Oxford Biomedicals, and Roche, and has received institutional research support from Amgen, AROG Pharmaceuticals, Bristol-Myers Squibb, Celgene, Jazz Pharmaceuticals, Novartis, Pfizer, and Sunesis. RMS has acted as a consultant or advisor for AbbVie, Actinium, and Agios, has received personal fees from Amgen, Argenx, AROG, Astellas, Astra Zeneca, BioLineRx, Celgene, Cornerstone, Daiichi Sankyo, Fujifilm, Jazz Pharmaceuticals, MacroGenics, Novartis, Ono/Theradex Oncology, Orsenix, Otsuka/Astex, Pfizer, Roche, Stemline Therapeutics, Takeda, and Trovagene, and has received institutional research support from AbbVie, Agios, AROG, and Novartis. The remaining authors declare no competing financial interests.